Transcription factors as targets for cancer therapy

被引：940
|
作者：
Darnell, JE [1 ]
机构：
[1] Rockefeller Univ, Lab Mol Cell Biol, New York, NY 10021 USA
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 10期
关键词：
D O I：
10.1038/nrc906
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A limited list of transcription factors are overactive in most human cancer cells, which makes them targets for the development of anticancer drugs. That they are the most direct and hopeful targets for treating cancer is proposed, and this is supported by the fact that there are many more human oncogenes in signalling pathways than there are oncogenic transcription factors. But how could specific transcription-factor activity be inhibited?.
引用
收藏
页码：740 / 749
页数：10
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