Hyperammonemia Induced Skeletal Muscle Mitochondrial Dysfunction Is Mediated By a Novel DRP1 Modification Induced Fission

被引:0
|
作者
Davuluri, Gangarao [1 ]
Kumar, Avinash [2 ]
Gangadhariah, Mahesha [2 ]
Kant, Sashi [1 ]
Clinton, Ryan [3 ]
Singh, Kulwant Aulak [2 ]
Qi, Xin [4 ]
Hoppel, Charles [3 ]
Mears, Jason [3 ]
Dasarathy, Srinivasan [2 ,5 ]
机构
[1] Cleveland Clin Fdn, Inflamat & Immun, Cleveland, OH USA
[2] Cleveland Clin Fdn, Inflammat & Immun, Cleveland, OH USA
[3] Case Western Reserve Univ, Pharmacol, Cleveland, OH 44106 USA
[4] Case Western Reserve Univ, Physiol, Cleveland, OH 44106 USA
[5] Cleveland Clin, Inflammat & Immun, Cleveland, OH 44106 USA
基金
美国国家卫生研究院;
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
843
引用
收藏
页码:498A / 498A
页数:1
相关论文
共 50 条
  • [31] Targeting Drp1 and mitochondrial fission for therapeutic immune modulation
    Simula, Luca
    Campanella, Michelangelo
    Campello, Silvia
    PHARMACOLOGICAL RESEARCH, 2019, 146
  • [32] Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1
    Chang, Chuang-Rung
    Blackstone, Craig
    MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE, 2010, 1201 : 34 - 39
  • [33] Mitochondrial Fission Protein Drp1 Regulates Platelet Function
    Jacob, Shancy
    Tistao, Marina
    Gomez, Abigail Ajanel
    Denorme, Frederik
    Kosaka, Yasuhiro
    Manne, Bhanu Kanth
    Guo, Li
    Campbell, Robert A.
    Rondina, Matthew T.
    Rowley, Jesse W.
    BLOOD, 2023, 142
  • [34] The role of Drp1 in adult skeletal muscle physiology
    Dablainville, Valentin
    Sanchez, Anthony M. J.
    JOURNAL OF PHYSIOLOGY-LONDON, 2020, 598 (21): : 4761 - 4763
  • [35] A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis
    Tanaka, Atsushi
    Youle, Richard J.
    MOLECULAR CELL, 2008, 29 (04) : 409 - 410
  • [36] DHA alleviates high glucose-induced mitochondrial dysfunction in Oreochromis niloticus by inhibiting DRP1-mediated mitochondrial fission
    Shen, Hui-Chao
    Chen, Zhi-Qiang
    Chen, Fang
    Chen, Sen
    Ning, Li-Jun
    Tian, Hong-Yan
    Xu, Chao
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 244
  • [37] Targeting the mitochondrial fission-mediator Drp1 is a potential therapeutic strategy for ventilator induced lung injury
    Pokharel, Marissa
    Flores, Alejandro Garcia
    Fu, Panfeng
    Lu, Qing
    Sun, Xutong
    Wang, Ting
    Black, Stephen
    FREE RADICAL BIOLOGY AND MEDICINE, 2023, 208 : S94 - S94
  • [38] Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis
    Kim, Dah Ihm
    Lee, Ki Hoon
    Gabr, Amr Ahmed
    Choi, Gee Euhn
    Kim, Jun Sung
    Ko, So Hee
    Han, Ho Jae
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2016, 1863 (11): : 2820 - 2834
  • [39] AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes
    Chen, Zhaowei
    Ma, Yiqiong
    Yang, Qian
    Hu, Jijia
    Feng, Jun
    Liang, Wei
    Ding, Guohua
    JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 235 (10) : 7433 - 7448
  • [40] Hyperammonemia Induced Skeletal Muscles Mitochondrial Dysfunction Are Reversed By Ammonia Withdrawal
    Kumar, Avinash
    Davuluri, Gangarao
    Allawy, Allawy
    Alchirazi, Khaled Alsabbagh
    Rennison, Julie H.
    Kant, Sashi
    Gangadhariah, Mahesha
    Van Wagoner, David
    Hoppel, Charles
    Dasarathy, Srinivasan
    HEPATOLOGY, 2018, 68 : 776A - 776A