TFG: a novel regulator of ULK1-dependent autophagy

被引：0

作者：

Cecconi, Francesco ^{[1
,2
,3
]}

Nazio, Francesca ^{[1
]}

机构：

[1] IRCCS, Bambino Gesu Childrens Hosp, Dept Pediat Hematooncol & Cell & Gene Theraphy, Viale San Paolo 15, I-00146 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Biol, Rome, Italy

[3] Danish Canc Soc Res Ctr, Unit Cell Stress & Survival, Copenhagen, Denmark

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2021年 / 8卷 / 04期

关键词：

ULK1; ERGIC; TFG; omegasome; neurological disorders;

D O I：

10.1080/23723556.2021.1945895

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases.

引用

页数：3

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