Melatonin prevents neonatal dexamethasone induced programmed hypertension: Histone deacetylase inhibition

被引:53
|
作者
Wu, Ting-Hsin [1 ]
Kuo, Hsuan-Chang [1 ]
Lin, I-Chun [1 ]
Chien, Shao-Ju [1 ]
Huang, Li-Tung [1 ,2 ]
Tain, You-Lin [1 ,3 ]
机构
[1] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan
[2] Chang Gung Univ, Dept Tradit Chinese Med, Linkow, Taiwan
[3] Kaohsiung Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung, Taiwan
来源
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2014年 / 144卷
关键词
Asymmetric dimethylarginine; Histone deacetylase; Hypertension; Melatonin; Oxidative stress; Renin-angiotensin system; BLOOD-PRESSURE; GENE-EXPRESSION; RENAL INJURY; RAT; KIDNEY; THERAPY; INFANTS; GROWTH; HEART;
D O I
10.1016/j.jsbmb.2014.07.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Adulthood hypertension can be programmed by corticosteroid exposure in early life. Oxidative stress, epigenetic regulation by histone deacetylases (HDACs), and alterations of renin-angiotensin system (RAS) are involved in the developmental programming of hypertension. We examined whether melatonin prevented neonatal dexamethasone (DEX)-induced programmed hypertension and how melatonin prevented these processes. We also examined whether HDAC inhibition by trichostatin A (TSA, a HDAC inhibitor) had similar effects. Male offspring were assigned to 5 groups (n = 6/group): control, DEX, melatonin, DEX + melatonin, and DEX + TSA. Male rat pups were injected i.p. with DEX on day 1 (0.5 mg/kg BW), day 2 (0.3 mg/kg BW), and day 3 (0.1 mg/kg BW) after birth. Melatonin was administered in drinking water at the dose of 0.01% during the lactation period. The DEX + TSA group received DEX and 0.5 mg/kg TSA subcutaneous injection once daily for 1 week. All rats were killed at 16 weeks of age. Neonatal DEX exposure induced hypertension in male offspring at 16 weeks of age, which melatonin prevented. Neonatal DEX exposure decreased gene expression related to apoptosis, nephrogenesis, RAS, and sodium transporters. Yet DEX treatment increased protein levels of HDAC-1, -2, and -3 in the kidney. Melatonin therapy preserved the decreases of gene expression and decreased HDACs. Similarly, HDAC inhibition prevented DEX-induced programmed hypertension. In conclusion, melatonin therapy exerts a long-term protection against neonatal DEX-induced programmed hypertension. Its beneficial effects include alterations of RAS components and inhibition of class I HDACs. Given that the similar protective effects of melatonin and TSA, melatonin might inhibit HDACs to epigenetic regulation of hypertension-related genes to prevent programmed hypertension. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:253 / 259
页数:7
相关论文
共 50 条
  • [21] Consequences of histone-deacetylase inhibition on drug-induced behaviours
    Sanchis-Segura, C.
    Aragon, C. M. G.
    BEHAVIOURAL PHARMACOLOGY, 2007, 18 : S89 - S89
  • [22] DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors
    Zhu, WG
    Lakshmanan, RR
    Beal, MD
    Otterson, GA
    CANCER RESEARCH, 2001, 61 (04) : 1327 - 1333
  • [23] Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice
    Chen, Youfang
    Du, Jianfeng
    Zhao, Yu Tina
    Zhang, Ling
    Lv, Guorong
    Zhuang, Shougang
    Qin, Gangjian
    Zhao, Ting C.
    CARDIOVASCULAR DIABETOLOGY, 2015, 14
  • [24] Histone Deacetylase 6 Inhibition Prevents Vaso-Occlusion and Pain in Sickle Cell Mice
    Nguyen, Aithanh
    Juliette, Joseph P.
    Wong, Alison
    Aronovich, Elena
    Abdullah, Maya
    Nguyen, Julia
    Abdulla, Fuad
    Chen, Chunsheng
    Khasabova, Iryna A.
    Belcher, John D.
    Vercellotti, Gregory M.
    Simone, Donald
    Beckman, Joan D.
    BLOOD, 2022, 140 : 2500 - 2501
  • [25] Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice
    Youfang Chen
    Jianfeng Du
    Yu Tina Zhao
    Ling Zhang
    Guorong Lv
    Shougang Zhuang
    Gangjian Qin
    Ting C Zhao
    Cardiovascular Diabetology, 14
  • [26] Maternal Melatonin Therapy Rescues Prenatal Dexamethasone and Postnatal High-Fat Diet Induced Programmed Hypertension in Male Rat Offspring
    Tain, You-Lin
    Sheen, Jiunn-Ming
    Yu, Hong-Ren
    Chen, Chih-Cheng
    Tiao, Mao-Meng
    Hsu, Chien-Ning
    Lin, Yu-Ju
    Kuo, Kuang-Che
    Huang, Li-Tung
    FRONTIERS IN PHYSIOLOGY, 2015, 6
  • [27] Apicidin, an inhibitor of histone deacetylase, prevents H-ras-induced invasive phenotype
    Kim, MS
    Son, MW
    Kim, WB
    Park, YI
    Moon, A
    CANCER LETTERS, 2000, 157 (01) : 23 - 30
  • [28] Histone Deacetylase Is Required for GA-Induced Programmed Cell Death in Maize Aleurone Layers
    Hou, Haoli
    Zheng, Xueke
    Zhang, Hao
    Yue, Mengxia
    Hu, Yan
    Zhou, Hong
    Wang, Qing
    Xie, Chengshen
    Wang, Pu
    Li, Lijia
    PLANT PHYSIOLOGY, 2017, 175 (03) : 1484 - 1496
  • [29] Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light
    Tain, You-Lin
    Lin, Yu-Ju
    Chan, Julie Y. H.
    Lee, Chien-Te
    Hsu, Chien-Ning
    BIOLOGY OF REPRODUCTION, 2017, 97 (04) : 636 - 643
  • [30] Inhibition of histone deacetylase 3 prevents free fatty acid-induced insulin resistance and inflammation through the regulation of mitochondrial metabolisms
    Jeon, J.
    Song, M.
    Lee, H.
    Choi, S. -E.
    Kang, Y.
    Kim, T.
    Kim, H.
    Han, S.
    Lee, N.
    Lee, K. -W.
    DIABETOLOGIA, 2020, 63 (SUPPL 1) : S242 - S242