Purpose: To compare the postoperative clinical outcomes after cataract surgery with implantation of bifocal intraocular lenses (IOLs) and extended depth of focus (EDOF) IOLs. Methods: A total of 60 patients were divided into three groups, and each group included 20 patients of 40 eyes: group A with a +3.25 D bifocal IOL in both eyes, group B with an EDOF IOL in both eyes, and group C with a +3.25 D bifocal in one eye and an EDOF IOL in the other eye. We retrospectively reviewed the patients' medical charts to analyze their binocular uncorrected visual acuities (UCVAs; distant, intermediate, and near) and refraction at postoperative 3 months. Results: The binocular distant UCVAs were 0.04 +/- 0.01, 0.05 +/- 0.02, and 0.04 +/- 0.01 in groups A, B, and C, respectively, and there were no differences between the groups (p > 0.05). The intermediate UCVAs were 0.16 +/- 0.01, 0.10 +/- 0.01, and 0.10 +/- 0.01, respectively, and group A was the lowest (A-B, p = 0.031; A-C, p = 0.018; B-C, p = 1.000). The near UCVAs were 0.05 +/- 0.01, 0.24 +/- 0.01, and 0.13 +/- 0.01, respectively, and there were significant differences between the groups (A-B, p < 0.001, A-C: p = 0.009; B-C, p = 0.003). Conclusions: There were no significant differences among the three groups in binocular distant UCVA, and groups B and C showed better intermediate UCVAs than group A. Near UCVA was ranked in the order of groups A, C, B.