CCAT2: A novel oncogenic long non-coding RNA in human cancers

被引：43
|
作者：
Xin, Yu [1 ,2 ]
Li, Zheng [2 ,3 ]
Zheng, Heyi [1 ,2 ]
Chan, Matthew T. V. [4 ]
Wu, William Ka Kei [4 ,5 ]
机构：
[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Dermatol, Beijing, Peoples R China
[2] Peking Union Med Coll, Beijing, Peoples R China
[3] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing, Peoples R China
[4] Chinese Univ Hong Kong, Dept Anaesthesia & Intens Care, Hong Kong, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, LKS Inst Hlth Sci, State Key Lab Digest Dis, Hong Kong, Hong Kong, Peoples R China
来源：
CELL PROLIFERATION | 2017年 / 50卷 / 03期
基金：
中国国家自然科学基金;
关键词：
POOR-PROGNOSIS; UP-REGULATION; METASTASIS; GROWTH; EXPRESSION;
D O I：
10.1111/cpr.12342
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Colon cancer-associated transcript 2 (CCAT2) was originally identified as an oncogenic long non-coding RNA in colorectal cancer. Since its discovery, the oncogenic role of CCAT2 has been increasingly demonstrated in human cancers. In this connection, CCAT2 upregulation is frequently reported and very often associated with tumour progression and poor clinical outcomes. Functionally, knockdown of CCAT2 could induce cancer cell apoptosis and suppress cell proliferation and invasiveness, suggesting that CCAT2 might be a therapeutic target. The present review summarized current literature concerning the expression and functional role of CCAT2 in human malignancies.
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页数：4
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