CCAT2: A novel oncogenic long non-coding RNA in human cancers

被引：43
|
作者：
Xin, Yu [1 ,2 ]
Li, Zheng [2 ,3 ]
Zheng, Heyi [1 ,2 ]
Chan, Matthew T. V. [4 ]
Wu, William Ka Kei [4 ,5 ]
机构：
[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Dermatol, Beijing, Peoples R China
[2] Peking Union Med Coll, Beijing, Peoples R China
[3] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing, Peoples R China
[4] Chinese Univ Hong Kong, Dept Anaesthesia & Intens Care, Hong Kong, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, LKS Inst Hlth Sci, State Key Lab Digest Dis, Hong Kong, Hong Kong, Peoples R China
来源：
CELL PROLIFERATION | 2017年 / 50卷 / 03期
基金：
中国国家自然科学基金;
关键词：
POOR-PROGNOSIS; UP-REGULATION; METASTASIS; GROWTH; EXPRESSION;
D O I：
10.1111/cpr.12342
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Colon cancer-associated transcript 2 (CCAT2) was originally identified as an oncogenic long non-coding RNA in colorectal cancer. Since its discovery, the oncogenic role of CCAT2 has been increasingly demonstrated in human cancers. In this connection, CCAT2 upregulation is frequently reported and very often associated with tumour progression and poor clinical outcomes. Functionally, knockdown of CCAT2 could induce cancer cell apoptosis and suppress cell proliferation and invasiveness, suggesting that CCAT2 might be a therapeutic target. The present review summarized current literature concerning the expression and functional role of CCAT2 in human malignancies.
引用
收藏
页数：4
相关论文
共 50 条
  • [1] CCAT2 is an oncogenic long non-coding RNA in pancreatic ductal adenocarcinoma
    Yi Cai
    Xiaomei Li
    Peng Shen
    Dong Zhang
    [J]. Biological Research, 51
  • [2] CCAT2 is an oncogenic long non-coding RNA in pancreatic ductal adenocarcinoma
    Cai, Yi
    Li, Xiaomei
    Shen, Peng
    Zhang, Dong
    [J]. BIOLOGICAL RESEARCH, 2018, 51
  • [3] CCAT1: a pivotal oncogenic long non-coding RNA in human cancers
    Xin, Yu
    Li, Zheng
    Shen, Jianxiong
    Chan, Matthew T. V.
    Wu, William Ka Kei
    [J]. CELL PROLIFERATION, 2016, 49 (03) : 255 - 260
  • [4] BANCR: a novel oncogenic long non-coding RNA in human cancers
    Zou, Yifan
    Li, Jianfa
    Chen, Yincong
    Xiao, Huizhong
    Zhang, Fuyou
    Yu, Dan
    Luo, Kewang
    [J]. ONCOTARGET, 2017, 8 (55) : 94997 - 95004
  • [5] Long non-coding RNA CCAT2 as a therapeutic target in colorectal cancer
    Fosselteder, Johannes
    Calin, George A.
    Pichler, Martin
    [J]. EXPERT OPINION ON THERAPEUTIC TARGETS, 2018, 22 (12) : 973 - 976
  • [6] CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations
    Redis, Roxana S.
    Sieuwerts, Anieta M.
    Look, Maxime P.
    Tudoran, Oana
    Ivan, Cristina
    Spizzo, Riccardo
    Zhang, Xinna
    de Weerd, Vanja
    Shimizu, Masayoshi
    Ling, Hui
    Buiga, Rares
    Pop, Victor
    Irimie, Alexandru
    Fodde, Riccardo
    Bedrosian, Isabella
    Martens, John W. M.
    Foekens, John A.
    Berindan-Neagoe, Ioana
    Calin, George A.
    [J]. ONCOTARGET, 2013, 4 (10) : 1748 - 1762
  • [7] PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers
    Xiong, Tiefu
    Li, Jianfa
    Chen, Fangfang
    Zhang, Fangting
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2019, 15 (04): : 847 - 856
  • [8] Exploring the role of CCAT1 and CCAT2 long non-coding RNA in colorectal carcinoma metastasis
    Thean, L.
    Li, H.
    Lo, M.
    Wong, M.
    Tang, C.
    Tan, K.
    Cheah, P.
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2019, 27 : 1558 - 1558
  • [9] HOTTIP: a critical oncogenic long non-coding RNA in human cancers
    Lian, Yifan
    Cai, Zeling
    Gong, Huangbo
    Xue, Songling
    Wu, Dongdong
    Wang, Keming
    [J]. MOLECULAR BIOSYSTEMS, 2016, 12 (11) : 3247 - 3253
  • [10] CRNDE: An important oncogenic long non-coding RNA in human cancers
    Zhang, Jiaming
    Yin, Minuo
    Peng, Gang
    Zhao, Yingchao
    [J]. CELL PROLIFERATION, 2018, 51 (03)
12345