Photoredox-Enabled Decarboxylative Synthesis of Unnatural α-Amino Acids

被引：12
|
作者：
Shatskiy, Andrey [1 ]
Karkas, Markus D. [1 ]
机构：
[1] KTH Royal Inst Technol, Dept Chem, S-10044 Stockholm, Sweden
来源：
SYNLETT | 2022年 / 33卷 / 02期
基金：
瑞典研究理事会;
关键词：
amino acids; decarboxylation; photoredox catalysis; radicals; DIASTEREOSELECTIVE RADICAL-ADDITION; CATALYTIC ASYMMETRIC-SYNTHESIS; CARBOXYLIC-ACIDS; LIGHT; ESTERS; FUNCTIONALIZATION; DERIVATIVES; ALKYLATION; ROUTE; MILD;
D O I：
10.1055/a-1499-8679
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Recently, development of general synthetic routes to unnatural alpha-amino acids has gained significant momentum, driven by the high demand for such building blocks in fundamental research within molecular and structural biology, as well as for development of new pharmaceuticals. Herein, we highlight the recent progress in employing photoredox-mediated synthetic methods for accessing unnatural alpha-amino acids with a focus on various decarboxylative radical-based strategies.
引用
收藏
页码：109 / 115
页数：7
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