Cobalt-Catalyzed Oxidative C(sp3)-H Phosphonylation for α-Aminophosphonates via C(sp3)-H/P(O)-H Coupling

被引：55
|
作者：
Lin, Binzhou [1 ,2 ]
Shi, Shanshan [1 ,2 ]
Lin, Rongcan [1 ,2 ]
Cui, Yiqun [1 ,2 ]
Fang, Meijuan [3 ]
Tang, Guo [1 ,2 ]
Zhao, Yufen [1 ,2 ]
机构：
[1] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Fujian, Peoples R China
[2] Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China
[3] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361000, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 12期
关键词：
C-H BONDS; TERTIARY-AMINES; EFFICIENT; AIR; PHOSPHONATION; COMPLEX; SYSTEM;
D O I：
10.1021/acs.joc.8b00674
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first oxidative C(sp(3))-H phosphonylation of tertiary aliphatic amines has been developed. The use of cobalt acetate as a catalyst, N-hydroxyphthalimide as a cocatalyst, and air as an oxidant enabled the conversion of tertiary aromatic and aliphatic amines into alpha-aminophosphonates in moderate to excellent yields under mild conditions via a cross dehydrogenative coupling reaction.
引用
收藏
页码：6754 / 6761
页数：8
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