Iron Catalyzed Oxidative C(sp3)-N Cross Coupling of Amides with C(sp3)-H via a Radical Process

被引：12
|
作者：
Li, Ze-lin [1 ]
Cai, Chun [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Chem Engn Coll, Nanjing 210094, Jiangsu, Peoples R China
来源：
CHEMISTRYSELECT | 2017年 / 2卷 / 26期
关键词：
C(sp(3))-H/N-H coupling; Fe(II)/Fe(III) catalytic cycle; Iron-catalyzed; ligand-free conditions; wide substrate scope; C-H BONDS; SIMPLE ALKANES; METAL-FREE; ARYL IODIDES; N-ARYLATION; SULFOXIMINES; CASCADE; FUNCTIONALIZATION; AMIDATION; AMINATION;
D O I：
10.1002/slct.201701537
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient iron-catalyzed oxidative N-H alkylation of amides with C(sp(3))-H in cycloalkanes, methylarenes and tert-Butyl peroxybenzoate was developed. This protocol proceeded smoothly without any ligand; and tolerated a broad range of substrates, not only various amides but also the inactive C(sp(3))-H bond containing compounds. Mechanistic details involving a Fe(II)/Fe(III) catalytic cycle and a single electron transfer (SET)-type process were also described.
引用
收藏
页码：8076 / 8079
页数：4
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