Stereocontrolled Synthesis as an Enabling Tool for the Configurational Assignment of Marine Polyketide Natural Products

被引：14

作者：

Lam, Nelson Y. S. ^{[1
]}

Paterson, Ian ^{[1
]}

机构：

[1] Univ Chem Lab, Lensfield Rd, Cambridge CB2 1EW, England

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 16期

关键词：

Aldol reactions; Natural products; Polyketides; Stereocontrol; Total synthesis; MICROTUBULE-STABILIZING MACROLIDE; STEREOCHEMICAL DETERMINATION; RELATIVE CONFIGURATION; STRUCTURAL ELUCIDATION; ALDOL CONDENSATIONS; CALLIPELTOSIDE-A; DRUG DISCOVERY; POWERFUL TOOL; ABSOLUTE; DICTYOSTATIN;

D O I：

10.1002/ejoc.201901243

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Marine polyketide natural products represent a fertile area of chemical space for the continual discovery of promising drug candidates. Advancements in spectroscopic and computational techniques have allowed for the increasingly facile structural and stereochemical determination of these biologically active molecules. However, their inherent architectural complexity often precludes a complete assignment even by the most discerning isolation chemists. This Minireview highlights how carefully conceived synthetic plans, employing highly stereocontrolled reactions, have enabled the configurational assignment of several polyketide natural products.

引用

页码：2310 / 2320

页数：11

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