Does Regional Lymph Node Irradiation Improve the Outcome of N0 and pN0 Breast Cancer?

被引：3

作者：

Gilliot, Olivier ^{[1
]}

Durando, Xavier ^{[2
]}

Abrial, Catherine ^{[3
]}

Belliere, Aurelie ^{[1
]}

Gimbergues, Pierre ^{[4
]}

Thivat, Emilie ^{[3
]}

Planchat, Eloise ^{[3
]}

Lapeyre, Michel ^{[1
]}

Kwiatkowski, Fabrice ^{[5
]}

Toledano, Ivan ^{[1
]}

Chollet, Philippe ^{[2
]}

Nabholtz, Jean-Marc ^{[2
]}

Verrelle, Pierre ^{[1
]}

机构：

[1] Ctr Jean Perrin, Dept Radiat Oncol, F-63011 Clermont Ferrand, France

[2] Ctr Jean Perrin, Dept Med Oncol, F-63011 Clermont Ferrand, France

[3] Ctr Jean Perrin, Dept Clin Res, F-63011 Clermont Ferrand, France

[4] Ctr Jean Perrin, Dept Surg, F-63011 Clermont Ferrand, France

[5] Ctr Jean Perrin, Dept Stat, F-63011 Clermont Ferrand, France

来源：

CANCER INVESTIGATION | 2010年 / 28卷 / 02期

关键词：

Neoadjuvant chemotherapy; Radiation therapy; Breast cancer; Node negative; POSTMASTECTOMY RADIATION IMPROVES; NEOADJUVANT CHEMOTHERAPY; POSTOPERATIVE RADIOTHERAPY; ADJUVANT RADIOTHERAPY; PREMENOPAUSAL WOMEN; MASTECTOMY; SURVIVAL; THERAPY; RISK; RECURRENCE;

D O I：

10.3109/07357900903179658

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study compares the outcome of 76 patients with N0 breast carcinoma, node-negative at axillary lymph node dissection (pN0) after neoadjuvant chemotherapy (NeoCT), treated with (RLNI+, 39 patients) or without (RLNI-, 37 patients) elective regional lymph node areas irradiation. For RLNI- and RLNI+ groups respectively at 10 years, survival without local-regional recurrence was 95% and 91% (p = .59), survival without distant metastasis was 97% and 78% (p = .018) and overall survival was 96% and 75% (p = .013). Clinical size <4 cm was a strong pronostic factor.

引用

页码：195 / 200

页数：6

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