A Review of Hyaluronic Acid and Hyaluronic Acid-based Hydrogels for Vocal Fold Tissue Engineering

被引:54
|
作者
Walimbe, Tanaya [1 ]
Panitch, Alyssa [1 ,2 ]
Sivasankar, Preeti M. [1 ,3 ]
机构
[1] Weldon Sch Biomed Engn, W Lafayette, IN USA
[2] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA
[3] Purdue Univ, Dept Speech Language & Hearing Sci, W Lafayette, IN 47907 USA
基金
美国国家卫生研究院;
关键词
Hyaluronic acid; Vocal fold; Tissue engineering; Scarring; Extracellular matrix; SYNTHETIC EXTRACELLULAR-MATRIX; CROSS-LINKED HYALURONAN; VISCOELASTIC SHEAR PROPERTIES; LAMINA PROPRIA; RABBIT MODEL; VOICE DISORDERS; HISTOLOGIC CHARACTERIZATION; GLOTTAL INSUFFICIENCY; POTENTIAL APPLICATION; GENE-EXPRESSION;
D O I
10.1016/j.jvoice.2016.11.014
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Vocal fold scarring is a common cause of dysphonia. Current treatments involving vocal fold augmentation do not yield satisfactory outcomes in the long term. Tissue engineering and regenerative medicine offer an attractive treatment option for vocal fold scarring, with the aim to restore the native extracellular matrix microenvironment and biomechanical properties of the vocal folds by inhibiting progression of scarring and thus leading to restoration of normal vocal function. Hyaluronic acid is a bioactive glycosaminoglycan responsible for maintaining optimum viscoelastic properties of the vocal folds and hence is widely targeted in tissue engineering applications. This review covers advances in hyaluronic acid-based vocal fold tissue engineering and regeneration strategies.
引用
收藏
页码:416 / 423
页数:8
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