Pestalactams A-C: novel caprolactams from the endophytic fungus Pestalotiopsis sp.

被引：44

作者：

Davis, Rohan A. ^{[1
]}

Carroll, Anthony R. ^{[1
]}

Andrews, Katherine T. ^{[1
,2
,5
]}

Boyle, Glen M. ^{[2
,5
]}

Tran, Truc Linh ^{[2
,5
]}

Healy, Peter C. ^{[1
]}

Kalaitzis, John A. ^{[3
]}

Shivas, Roger G. ^{[4
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Queensland Inst Med Res, Herston, Qld 4006, Australia

[3] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

[4] Queensland Primary Ind & Fisheries, Indooroopilly, Qld 4068, Australia

[5] Griffith Med Res Coll, Herston, Qld, Australia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 08期

关键词：

ANTIMALARIAL ACTIVITY; GENUS XYLARIA; METABOLITE; CHLOROPEROXIDASE; MICROFUNGUS;

D O I：

10.1039/b924169h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical investigations of a fermentation culture from the endophytic fungus Pestalotiopsis sp. yielded three novel caprolactams, pestalactams A-C (1-3). The structures of 1-3 were determined by analysis of 1D and 2D-NMR, UV, IR, and MS data. The structure of pestalactam A was confirmed following single crystal X-ray diffraction analysis. Pestalactams A-C are the first C-7 alkylated caprolactam natural products to be reported. Pestalactams A(1) and B(2) were tested against two different strains of the malaria parasite Plasmodium falciparum (3D7 and Dd2), and the mammalian cell lines, MCF-7 and NFF, and showed modest in vitro activity in all assays.

引用

页码：1785 / 1790

页数：6

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