Down-regulation of phospholipase C-β1 following chronic muscarinic receptor activation

被引：5
|
作者：
Sorensen, SD
Linseman, DA
Fisher, SK
机构：
[1] Univ Michigan, Mental Hlth Res Inst, Neurosci Lab, Ann Arbor, MI 48104 USA
[2] Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48104 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 346卷 / 01期
关键词：
G protein-coupled receptor; phosphoinositide-specific phospholipase C; oxotremorine-M;
D O I：
10.1016/S0014-2999(98)00125-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To determine whether prolonged activation of a phospholipase C-coupled receptor can lead to a down-regulation of its effector enzyme, SH-SY5Y neuroblastoma cells were incubated for 24 h with the muscarinic receptor agonist, oxotremorine-M. Under these conditions, significant reductions (46-53%) in muscarinic cholinergic receptor density, G(alpha q/11) and phospholipase C-beta(1) (but not the beta(3)-or gamma(1) isoforms) were observed. These results suggest that a selective down-regulation of phospholipase C-beta(1) may play a role in adaptation to chronic muscarinic receptor activation. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：R1 / R2
页数：2
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