Thymidylate synthase gene polymorphism and its association with relapse in childhood B-cell precursor acute lymphoblastic leukemia

被引：0
|
作者：
Lauten, M [1 ]
Asgedom, G [1 ]
Welte, K [1 ]
Schrappe, M [1 ]
Stanulla, M [1 ]
机构：
[1] Hannover Med Sch, D-30625 Hannover, Germany
来源：
HAEMATOLOGICA | 2003年 / 88卷 / 03期
关键词：
thymidylate synthase; childhood ALL; relapse; ALL-BFM;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated a tandem-repeat polymorphism within the promoter region of the thymidylate synthase gene in 40 matched pairs of relapsed and non-relapsed childhood B-cell precursor acute lymphoblastic leukemia patients. This polymorphism has previously been suggested to influence treatment outcome in childhood acute lymphoblastic leukemia. In our study, no association between thymidylate synthase genotype and risk of relapse was found.
引用
收藏
页码：353 / 354
页数：2
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