Adhesive and Signaling Functions of Cadherins and Catenins in Vertebrate Development

被引：126

作者：

Stepniak, Ewa ^{[1
]}

Radice, Glenn L. ^{[2
]}

Vasioukhin, Valeri ^{[1
,3
,4
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

[2] Thomas Jefferson Univ, Jefferson Med Coll, Dept Med, Ctr Translat Med, Philadelphia, PA 19107 USA

[3] Univ Washington, Inst Stem Cell & Regenerat Med, Seattle, WA 98195 USA

[4] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2009年 / 1卷 / 05期

关键词：

CELL-CELL ADHESION; ALPHA-E-CATENIN; VASCULAR ENDOTHELIAL-CADHERIN; HAIR FOLLICLE MORPHOGENESIS; BETA-CATENIN; N-CADHERIN; WNT/BETA-CATENIN; TYROSINE PHOSPHORYLATION; P120; CATENIN; VE-CADHERIN;

D O I：

10.1101/cshperspect.a002949

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Properly regulated intercellular adhesion is critical for normal development of all metazoan organisms. Adherens junctions play an especially prominent role in development because they link the adhesive function of cadherin-catenin protein complexes to the dynamic forces of the actin cytoskeleton, which helps to orchestrate a spatially confined and very dynamic assembly of intercellular connections. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are linked to several major developmental signaling pathways crucial for normal morphogenesis. In this article we will highlight the key genetic studies that uncovered the role of cadherin-catenin proteins in vertebrate development and discuss the potential role of these proteins as molecular biosensors of external cellular microenvironment that may spatially confine signaling molecules and polarity cues to orchestrate cellular behavior throughout the complex process of normal morphogenesis.

引用

页数：23

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[J]. MOLECULAR AND CELLULAR NEUROSCIENCE, 1998, 12 (4-5) : 240 - 255
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[23] Cadherins and catenins: Role in signal transduction and tumor progression
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[25] Cadherins and catenins, Wnts and SOXs:: Embryonic patterning in Xenopus
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[28] Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment
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