The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer

被引:120
|
作者
Savant, Sudha S. [1 ]
Sriramkumar, Shruthi [2 ]
O'Hagan, Heather M. [1 ,3 ]
机构
[1] Indiana Univ Sch Med, Med Sci, Bloomington, IN 47405 USA
[2] Indiana Univ, Cell Mol & Canc Biol Grad Program, Bloomington, IN 47405 USA
[3] Indiana Univ, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46202 USA
关键词
inflammation; epithelial ovarian cancer; cytokines; reactive oxygen species; growth factors; ENDOTHELIAL GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANCHORAGE-INDEPENDENT GROWTH; FACTOR RECEPTOR EXPRESSION; INTERLEUKIN-6; SERUM-LEVELS; C-REACTIVE PROTEIN; NF-KAPPA-B; LYSOPHOSPHATIDIC ACID; CELL-PROLIFERATION;
D O I
10.3390/cancers10080251
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Inflammation plays a role in the initiation and development of many types of cancers, including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a type of EOC. There are connections between EOC and both peritoneal and ovulation-induced inflammation. Additionally, EOCs have an inflammatory component that contributes to their progression. At sites of inflammation, epithelial cells are exposed to increased levels of inflammatory mediators such as reactive oxygen species, cytokines, prostaglandins, and growth factors that contribute to increased cell division, and genetic and epigenetic changes. These exposure-induced changes promote excessive cell proliferation, increased survival, malignant transformation, and cancer development. Furthermore, the pro-inflammatory tumor microenvironment environment (TME) contributes to EOC metastasis and chemoresistance. In this review we will discuss the roles inflammation and inflammatory mediators play in the development, progression, metastasis, and chemoresistance of EOC.
引用
收藏
页数:30
相关论文
共 50 条
  • [31] Re: Possible role of ovarian epithelial inflammation in ovarian cancer - Response
    Ness, RB
    Cottreau, C
    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (02): : 163 - 163
  • [32] Novel Role of Titin in the Development of Chemoresistance in Ovarian Cancer.
    Harper, Amy K.
    Fletcher, Nicole M.
    Fan, Rong
    Morris, Robert
    Saed, Ghassan M.
    REPRODUCTIVE SCIENCES, 2019, 26 : 159A - 159A
  • [33] Inflammatory mediators of prostate cancer metastasis
    Martinez-Ferrer, Magaly
    Qi, Ying
    Sanchez, Maria M.
    Bhowmick, Neil A.
    CANCER RESEARCH, 2011, 71
  • [34] Role of human epididymis protein 4 in chemoresistance and prognosis of epithelial ovarian cancer
    Lee, Seungho
    Choi, Seowon
    Lee, Yookyung
    Chung, Donghae
    Hong, Suntaek
    Park, Nohhyun
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2017, 43 (01) : 220 - 227
  • [35] RETRACTED: KDM3A confers metastasis and chemoresistance in epithelial ovarian cancer (Retracted Article)
    Pa, Meili
    Naizaer, Gulimire
    Seyiti, Ayinuer
    Kuerbang, Gulina
    JOURNAL OF MOLECULAR HISTOLOGY, 2015, 46 (06) : 511 - 518
  • [36] Identification of mediators of chemoresistance in a heterogeneous tumor model of ovarian cancer
    Croft, K. M.
    Cornelison, R.
    Llaneza, D. C.
    Landen, C. N., Jr.
    GYNECOLOGIC ONCOLOGY, 2019, 154 : 86 - 86
  • [37] Role of Glutathione in Cancer Progression and Chemoresistance
    Traverso, Nicola
    Ricciarelli, Roberta
    Nitti, Mariapaola
    Marengo, Barbara
    Furfaro, Anna Lisa
    Pronzato, Maria Adelaide
    Marinari, Umberto Maria
    Domenicotti, Cinzia
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013, 2013
  • [38] Role of CSF-1 in progression of epithelial ovarian cancer
    Chambers, Setsuko K.
    FUTURE ONCOLOGY, 2009, 5 (09) : 1429 - 1440
  • [39] The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer
    Parafiniuk, Klaudia
    Skiba, Wiktoria
    Pawlowska, Anna
    Suszczyk, Dorota
    Maciejczyk, Aleksandra
    Wertel, Iwona
    BIOMEDICINES, 2022, 10 (04)
  • [40] The role of TWIST1 in chemoresistance and metastasis in ovarian cancer - potential therapeutic applications
    Roberts, Cai
    Han, Ernest S.
    Lowe, Gina
    Finlay, James
    Wilczynski, Sharon
    Ghoda, Lucy
    Glackin, Carlotta
    Dellinger, Thanh H.
    CLINICAL CANCER RESEARCH, 2013, 19