Stereoselective Synthesis of Multifunctional Spirooxindole-Dihydrofuran Derivatives

被引：4

作者：

Azimi, Razieh ^{[1
]}

Baharfar, Robabeh ^{[2
]}

Bagheri, Hashem ^{[2
]}

机构：

[1] Agr Res Educ & Extens Org AREEO, Res Inst Forests & Rangelands, Tehran, Iran

[2] Univ Mazandaran, Fac Chem, Babolsar, Iran

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2022年 / 42卷 / 08期

关键词：

Isatin; multicomponent reaction; multifunctional spirooxindole-dihydrofurans; stereoselective synthesis; POT MULTICOMPONENT SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; EFFICIENT; ANTIOXIDANT; DESIGN; YLIDES; SBA-15; DABCO;

D O I：

10.1080/10406638.2021.1933106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient protocol for the diastereoselective synthesis of novel spirooxindole-dihydrofurans has been developed by the three-component condensation of isatin derivatives, 3-cyanoacetyl indole, and N-phenacylpyridinium bromide in the presence of triethylamine base. The reaction was carried out in ethanol under reflux conditions, and various dihydrofuranyl spirooxindoles were obtained in high yields with good to excellent stereoselectivity.

引用

页码：5272 / 5281

页数：10

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