Structure-activity relationships of some complex I inhibitors

被引：99
|
作者：
Miyoshi, H [1 ]
机构：
[1] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Sakyo Ku, Kyoto 60601, Japan
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 1998年 / 1364卷 / 02期
关键词：
complex I; mitochondrion; respiratory inhibitor; structure-activity relationship;
D O I：
10.1016/S0005-2728(98)00030-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A wide variety of complex I inhibitors act at or close to the ubiquinone reduction site. Identification of the structural factors required for exhibiting inhibitory actions on the basis of structure-activity relationships is useful to elucidate the manner in which inhibitors interact with the enzyme. This review summarizes studies on the structure-activity relationship of rotenoids, piericidins, capsaicins, pyridinium-type inhibitors and modern synthetic agrochemicals acting at mitochondrial complex I. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：236 / 244
页数：9
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