Quantitative structure-activity relationships of some HIV-protease inhibitors

被引：15
|
作者：
Gupta, SP [1 ]
Babu, MS [1 ]
Kaw, N [1 ]
机构：
[1] Birla Inst Technol & Sci, Pilani 333031, Rajasthan, India
来源：
JOURNAL OF ENZYME INHIBITION | 1999年 / 14卷 / 02期
关键词：
quantitative structure-activity relationship; HIV-1 protease inhibitors; cycloalkylpyranones;
D O I：
10.3109/14756369909036549
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A quantitative structure-activity relationship (QSAR) study has been made on different series of cycloalkylpyranones acting as human-immunodeficiency-virus type 1 (HIV-1) protease inhibitors. The results suggest that the enzyme binding affinity of the: compounds would be favoured by a cyclooctyl ring, a 3-cyclopropylphenylmethyl substituent at the pyranone ring, and a 4-CN-2-pyridine-, an N-Me-imidazole-, or a 3- or 4-CN-phenyl-sulfonamide group at the meta position of the phenyl ring of the 3-substituent.
引用
收藏
页码：109 / 123
页数：15
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