Activatable probes for diagnosis and biomarker detection by MRI

被引：42

作者：

Carril, Monica ^{[1
,2
]}

机构：

[1] CIC BiomaGUNE, Paseo Miramon 182, San Sebastian 20014, Spain

[2] Ikerbasque, Basque Fdn Sci, E-48011 Bilbao, Spain

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 23期

关键词：

MAGNETIC-RESONANCE SIGNALS; CONTRAST AGENTS; IN-VIVO; F-19; NMR; SILICA NANOPARTICLES; BETA-GALACTOSIDASE; ENZYMATIC-ACTIVITY; PROTEASE ACTIVITY; IMAGING SIGNALS; METAL-IONS;

D O I：

10.1039/c7tb00093f

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Magnetic resonance imaging (MRI) is a non-invasive imaging technique with widespread use in diagnosis. Frequently, contrast in MRI is enhanced with the aid of a contrast agent, among which smart, responsive, OFF/ON or activatable probes are of particular interest. These kinds of probes elicit a response to selective stimuli, evidencing the presence of enzymes or acidic pH, for instance. In this review, we will focus on smart probes that are detectable by both H-1 and F-19 MRI, frequently based on nanomaterials. We will discuss the triggering factors and the strategies employed thus far to activate each probe.

引用

下载

页码：4332 / 4347

页数：16

共 50 条

[41] Activatable Chemiluminescent Molecular Probes for Bioimaging and Biosensing
Yang, Yanling
Zhang, Fan
Analysis and Sensing, 2021, 1 (02): : 75 - 89
[42] Light-activatable probes for cancer biology
Beharry, Andrew
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
[43] Activatable imaging probes with amplified fluorescent signals
Lee, Seulki
Park, Kyeongsoon
Kim, Kwangmeyung
Choi, Kuiwon
Kwon, Ick Chan
CHEMICAL COMMUNICATIONS, 2008, (36) : 4250 - 4260
[44] Nanoparticle-Based Activatable Probes for Bioimaging
Ma, Tiancong
Xia, Tian
ADVANCED BIOLOGY, 2021, 5 (01):
[45] Cancer Diagnosis and Treatment Guidance: Role of MRI and MRI Probes in the Era of Molecular Imaging
Lu, Jingjing
Feng, Feng
Jin, Zhengyu
CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2013, 14 (08) : 714 - 722
[46] Diffusion Kurtosis Imaging: A Possible MRI Biomarker for AD Diagnosis?
Struyfs, Hanne
Van Hecke, Wim
Veraart, Jelle
Sijbers, Jan
Slaets, Sylvie
De Belder, Maya
Wuyts, Laura
Peters, Benjamin
Sleegers, Kristel
Robberecht, Caroline
Van Broeckhoven, Christine
De Belder, Frank
Parizel, Paul M.
Engelborghs, Sebastiaan
JOURNAL OF ALZHEIMERS DISEASE, 2015, 48 (04) : 937 - 948
[47] DEVELOPING APTAMER PROBES FOR DETECTION OF ACUTE MYELOGENOUS LEUKEMIA AND FOR BIOMARKER DISCOVERY
Li, Ying
Jiang, Guohua
Yang, Minli
Li, Wenjing
Al-Quran, Samer Z.
Carter, Christopher
CYTOMETRY PART B-CLINICAL CYTOMETRY, 2013, 84 (06) : 413 - 414
[48] Multivalent dendrimeric peptides as new biomarker probes for the detection of cancer metastasis
Coulup, Sara K.
Saludes, Jonel P.
Yin, Hang
CANCER RESEARCH, 2012, 72
[49] Improvement of MRI probes to allow efficient detection of gene expression
Högemann, D
Josephson, L
Weissleder, R
Basilion, JP
BIOCONJUGATE CHEMISTRY, 2000, 11 (06) : 941 - 946
[50] DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells
Brennecke, Benjamin
Wang, Qinghua
Haap, Wolfgang
Grether, Uwe
Hu, Hai-Yu
Nazare, Marc
BIOCONJUGATE CHEMISTRY, 2021, 32 (04) : 702 - 712

← 1 2 3 4 5 →