Contribution of bone marrow derived cells to the pancreatic tumor microenvironment

被引：18
|
作者：
Scarlett, Christopher J. [1 ,2 ]
机构：
[1] Univ Newcastle, Sch Environm & Life Sci, Food Bioact & Pancreat Canc Biol Grp, Ourimbah, NSW 2258, Australia
[2] Garvan Inst Med Res, Canc Res Program, Sydney, NSW, Australia
来源：
FRONTIERS IN PHYSIOLOGY | 2013年 / 4卷
关键词：
bone marrow derived stem cells; pancreatic cancer; stroma; pancreatic stellate cells; fibrosis; immunosuppression; neovascularization; HEMATOPOIETIC STEM-CELLS; STELLATE CELLS; SUPPRESSOR-CELLS; DUCTAL ADENOCARCINOMA; IN-VIVO; IMMUNE SUPPRESSION; MAST-CELLS; BETA-CELLS; ADULT STEM; RAT MODEL;
D O I：
10.3389/fphys.2013.00056
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Pancreatic cancer is a complex, aggressive, and heterogeneous malignancy driven by the multifaceted interactions within the tumor microenvironment. While it is known that the tumor rnicroenvironment accommodates many cell types, each playing a key role in tumorigenesis, the major source of these stromal cells is not well-understood. This review examines the contribution of bone marrow-derived cells (BMDC) to pancreatic carcinogenesis, with respect to their role in constituting the tumor microenvironment. In particular, their role in supporting fibrosis, immunosuppression, and neovascularization will be discussed.
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页数：7
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