Synaptopathy, circuitopathy and the computational biology of Huntington's disease

被引：6
|
作者：
Hannan, Anthony J. [1 ,2 ]
机构：
[1] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne Brain Ctr, Parkville, Vic, Australia
[2] Univ Melbourne, Dept Anat & Neurosci, Parkville, Vic, Australia
来源：
BMC BIOLOGY | 2018年 / 16卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
NEURONS;
D O I：
10.1186/s12915-018-0539-y
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Huntington's disease (HD) is one of the most common tandem repeat disorders and presents as a unique trilogy of cognitive, psychiatric and motor symptoms. One of the major mysteries of HD is why it selectively affects specific neuronal populations. A new article in BMC Biology provides a piece in the puzzle of pathogenesis. By demonstrating the delicate relationship between cortical and striatal neurons, it provokes broader questions of how we might understand HD as a disorder of synapses, neural circuits and systems biology.
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页数：3
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