Enantioselective synthesis of cyclic quaternary α-amino acid derivatives by chiral phosphoric acid catalysis

被引：19

作者：

Wang, Lei ^{[1
]}

Rahman, Abdul ^{[1
]}

Lin, Xufeng ^{[1
]}

机构：

[1] Zhejiang Univ, Lab Asymmetr Catalysis & Synth, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 28期

基金：

中国国家自然科学基金;

关键词：

CRAFTS ALKYLATION REACTION; ASYMMETRIC-SYNTHESIS; BRONSTED ACID; STEREOSELECTIVE-SYNTHESIS; CARBON STEREOCENTERS; MANNICH REACTIONS; RECENT PROGRESS; INDOLES; CONSTRUCTION; INHIBITORS;

D O I：

10.1039/c7ob01149k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly enantioselective aza-Friedel-Crafts reaction of N-sulfonyl cyclic ketimines with indoles catalyzed by chiral phosphoric acids has been developed. This methodology provides an efficient and facile route to indole-containing chiral cyclic alpha-amino acid derivatives bearing a quaternary stereocenter in high yields and up to 98% enantioselectivity.

引用

页码：6033 / 6041

页数：9

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