Epidemiology of myasthenia gravis with anti-muscle specific kinase antibodies in the Netherlands

被引：54
|
作者：
Niks, Erik H.
Kuks, Jan B. M.
Verschuuren, Jan J. G. M.
机构：
[1] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands
[2] Univ Groningen, Med Ctr, Dept Neurol, Groningen, Netherlands
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2007年 / 78卷 / 04期
关键词：
D O I：
10.1136/jnnp.2006.102517
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The epidemiology of myasthenia gravis subtypes and the frequency of antibodies to muscle-specific kinase (MuSK) was studied in patients with generalised myasthenia gravis without anti-acetylcholine receptor antibodies who had an onset of symptoms between 1990 and 2004 in a well-defined region in the Netherlands. The nationwide prevalence and incidence of myasthenia gravis with anti-MuSK antibodies were also studied. MuSK antibodies were found in 22% of patients with generalised myasthenia gravis without anti-acetylcholine receptor antibodies. Nationwide, 35 patients with MuSK myasthenia gravis were identified, yielding a prevalence of 1.9 per million (95% confidence interval (CI) 1.22 to 2.59) and an annual incidence 0.10 per million person-years (95% CI 0.06 to 0.14).
引用
收藏
页码：417 / 418
页数：2
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