The synthesis of imidazoles and evaluation of their antioxidant and antifungal activities

被引：16
|
作者：
Ghorbani-Vaghei, Ramin [1 ]
Izadkhah, Vida [1 ]
Mahmoodi, Jafar [1 ]
Karamian, Roya [2 ]
Khoei, Masoumeh Ahmadi [2 ]
机构：
[1] Bu Ali Sina Univ, Fac Chem, Hamadan 6517838683, Iran
[2] Bu Ali Sina Univ, Fac Sci, Dept Biol, POB 65175-4161, Hamadan, Iran
来源：
MONATSHEFTE FUR CHEMIE | 2018年 / 149卷 / 08期
关键词：
Imidazole; Antioxidant; Fungicide; Phosphotungstic acid; Magnetic properties; TETRASUBSTITUTED IMIDAZOLES; IONIC LIQUID; DERIVATIVES; ACID;
D O I：
10.1007/s00706-018-2167-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tri- and tetra-substituted imidazole compounds were synthesized through in situ oxidation-condensation in the presence of catalytic amount of H(2)PW(12)O(40)A loaded on the ionic liquid-functionalized magnetic nanoparticles. Then, the antioxidant and antifungal activities of the new imidazoles were evaluated. The effectiveness of the samples as DPPH radical scavengers was confirmed by the measured IC50 values and thiophenyl-containing product showed the best IC50 of 0.12 when compared to the standard ascorbic acid. Moreover, all compounds have antifungal activity against Fusarium oxysporum. [GRAPHICS] .
引用
收藏
页码：1447 / 1452
页数：6
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