Meta analysis of the correlation between Helicobacter pylori infection and coronary heart disease

Objective: To investigate the relationship between Helicobacter pylori infection and coronary heart disease. Methods: Pubmed, Medline and Embase databases were retrieved by a computer. Studies published in English from January 2000 to June 2015 that reported on association between coronary heart disease and infection of helicobacter pylori were selected. Meta analysis was used to evaluate the combined OR value and the 95% confidence interval (95% CI) after merging. Results: There were 18 studies included in this Meta analysis, the combined OR was 1.64 and 95% CI was 1.22-2.23 that calculated by a random effect model. 12 studies on association between coronary heart disease and Helicobacter pylori infection were collected. The Meta analysis showed that there was a certain relationship between the coronary heart disease and Helicobacter pylori infection, and the combined OR was 1.96, 95% CI was 1.28-3.02. Conclusion: Infection with helicobacter pylori was associated with coronary heart disease. Therefore, health education should be strengthened to reduce the chance of helicobacter pylori infection and prevent the occurrence of coronary heart disease.