Synthesis of some fluorinated acids, ketones and alcohols derived from 3,3,3-trifluoropropionic acid

被引：13
|
作者：
Xiao, L [1 ]
Kitazume, T [1 ]
机构：
[1] Tokyo Inst Technol, Dept Bioengn, Midori Ku, Yokohama, Kanagawa 226, Japan
来源：
JOURNAL OF FLUORINE CHEMISTRY | 1997年 / 86卷 / 01期
关键词：
enzymatic hydrolysis; 3-fluoro-2-alkenoic acids; 2,2,2-trifluoroethyl alkyl ketones;
D O I：
10.1016/S0022-1139(97)00068-7
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The stereoselective synthesis of 3-fluoro-2-alkenoic acids was achieved by the reaction of lithium 3,3,3-trifluoropropionate with Grignard reagents. 2,2,2-Trifluoroethyl alkyl ketones were prepared by the reaction of 3,3,3-trifluoropropionic acid chloride with either lithium dialkylcuprates or magnesium dialkylcuprates. Optically active 1,1,1-uifluoro-3-alkanols were obtained by the enzymatic hydrolysis of the corresponding acetates. (C) 1997 Elsevier Science S.A.
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页码：99 / 104
页数：6
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