Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5+2] annulation

被引：50
|
作者：
Cui, Li [1 ]
Ye, Longwu [1 ]
Zhang, Liming [1 ]
机构：
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 19期
关键词：
PONNDORF-VERLEY REDUCTION; ASYMMETRIC REDUCTION; RING-CLOSURE; AU CATALYSIS; MIGRATION; ANALOGS; ALLENES; OLEFINS; KETONES; ALKYNES;
D O I：
10.1039/c001314e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A surprisingly efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation is developed. This reaction involves a key gold catalysis and shows generally high regioselectivities and good to excellent diastereoselectivities.
引用
收藏
页码：3351 / 3353
页数：3
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