Study of the Room-Temperature Synthesis of Oxime Ethers by using a Super Base

被引：2

作者：

Kosmalski, Tomasz ^{[1
]}

Studzinska, Renata ^{[1
]}

Daniszewska, Natalia ^{[1
]}

Ullrich, Malgorzata ^{[2
]}

Sikora, Adam ^{[3
]}

Marszaell, Michal ^{[3
]}

Modzelewska-Banachiewiciz, Bozena ^{[1
]}

机构：

[1] Nicolaus Copernicus Univ, Fac Pharm, Coll Med, Dept Organ Chem, Jurasza 2, PL-85067 Bydgoszcz, Poland

[2] Nicolaus Copernicus Univ, Fac Chem, Dept Organ Chem, Gagarina 7, PL-87100 Torun, Poland

[3] Nicolaus Copernicus Univ, Coll Med, Med Chem Dept, Fac Pharm, Jurasza 2, PL-85067 Bydgoszcz, Poland

来源：

CHEMISTRYOPEN | 2018年 / 7卷 / 07期

关键词：

green chemistry; NMR spectroscopy; oxime ethers; synthesis; waste prevention; ONE-POT SYNTHESIS; DERIVATIVES; ANTICONVULSANT; INHIBITORS; REDUCTION; ANALOGS; SERIES; ARYL;

D O I：

10.1002/open.201800098

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, we present a convenient method for the synthesis of oxime ethers by reacting oximes with various chlorides (alkyl, functionalized alkyl, and benzyl) and with the subsequent use of a super base-pulverized potassium hydroxide in DMSO. The reactions take place at room temperature and the products are obtained in high yields. The final products were received within 2min to 3h. In addition, the compounds do not require chromatographic separation. The structure elucidation of the titled compounds was performed by using (HNMR)-H-1 and (CNMR)-C-13 spectroscopy as well as mass spectrometry. The presented method of synthesis for oxime ethers is environmentally friendly, because neither water cooling or heating of the reaction mixture/solvents (necessary for chromatographic purification) is required. The synthesis can be carried out very easily on a large scale.

引用

页码：551 / 557

页数：7

共 50 条

[41] POLYIODINATION ON BENZENE AT ROOM-TEMPERATURE A REGIOSELECTIVE SYNTHESIS OF DERIVATIVES
BARLUENGA, J
GONZALEZ, JM
GARCIAMARTIN, MA
CAMPOS, PJ
TETRAHEDRON LETTERS, 1993, 34 (24) : 3893 - 3896
[42] ROOM-TEMPERATURE SYNTHESIS OF STERICALLY-HINDERED PORPHYRINS
WAGNER, RW
LINDSEY, JS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1988, 196 : 184 - INOR
[43] Room-temperature chemical synthesis of C2
Kazunori Miyamoto
Shodai Narita
Yui Masumoto
Takahiro Hashishin
Taisei Osawa
Mutsumi Kimura
Masahito Ochiai
Masanobu Uchiyama
Nature Communications, 11
[44] POLARIZED FLUORESCENCE STUDY OF RETINALS AT ROOM-TEMPERATURE
HOTCHANDANI, S
PAQUIN, P
LEBLANC, RM
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1978, 56 (15): : 1985 - 1988
[45] Room-Temperature Eutectic Synthesis for Upcycling of Cathode Materials
Hawley, W. Blake
Li, Mengya
Li, Jianlin
BATTERIES-BASEL, 2023, 9 (10):
[46] Room-temperature synthesis and characterization of new ZnPO and ZnAsO
1600, (113):
[47] Room-Temperature Chemical Synthesis of Silver Telluride Nanowires
Samal, A. K.
Pradeep, T.
JOURNAL OF PHYSICAL CHEMISTRY C, 2009, 113 (31): : 13539 - 13544
[48] Computational study of the dynamics and thermodynamics of room-temperature
Margulis, CJ
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U219 - U219
[49] Room-temperature ionic liquids for synthesis of advanced materials
Dai, S
Yuan, CY
Liang, CD
Makote, RD
Luo, HM
PROCEEDINGS OF THE 6TH INTERNATIONAL SYMPOSIUM ON MOLTEN SALT CHEMISTRY AND TECHNOLOGY, 2001, : 419 - 427
[50] Room-temperature ionic liquids: For a difference in the supramolecular synthesis
Pedireddi, V. R.
Shimpi, Manishkumar R.
Yakhmi, J. V.
MACROMOLECULAR SYMPOSIA, 2006, 241 : 83 - 87

← 1 2 3 4 5 →