Skin Barrier and Inflammation Genes Associated with Atopic Dermatitis are Regulated by Interleukin-13 and Modulated by Tralokinumab In vitro

被引：16
|
作者：
Tollenaere, Maxim A. X. [1 ]
Litman, Thomas [1 ]
Moebus, Lena [2 ]
Rodriguez, Elke [2 ]
Stoelzl, Dora [2 ]
Drerup, Katharina [2 ]
Werfel, Thomas [3 ]
Schmitt, Jochen [4 ]
Norsgaard, Hanne [1 ]
Weidinger, Stephan [2 ]
机构：
[1] LEO Pharma AS, Skin Res, Ballerup, Denmark
[2] Univ Hosp Schleswig Holstein, Dept Dermatol Venereol & Allergol, Campus Kiel, Kiel, Germany
[3] Hannover Med Sch, Dept Dermatol Allergol & Venereol, Div Immunodermatol & Allergy Res, Hannover, Germany
[4] Tech Univ Dresden, Med Fac Carl Gustav Carus, Ctr Evidence Based Hlth Care ZEGV, Dresden, Germany
来源：
ACTA DERMATO-VENEREOLOGICA | 2021年 / 101卷
关键词：
D O I：
10.2340/00015555-3810
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [21] Asthma and Atopic Dermatitis: A Review of Targeted Inhibition of Interleukin-4 and Interleukin-13 As Therapy for Atopic Disease
    Buzney, Catherine D.
    Gottlieb, Alice B.
    Rosmarin, David
    JOURNAL OF DRUGS IN DERMATOLOGY, 2016, 15 (02) : 165 - 171
  • [22] The effect of pimecrolimus on expression of genes associated with skin barrier dysfunction in atopic dermatitis skin lesions
    Grzanka, Alicja
    Zebracka-Gala, Jadwiga
    Rachowska, Regina
    Bozek, Andrzej
    Kowalska, Malgorzata
    Jarzab, Jerzy
    EXPERIMENTAL DERMATOLOGY, 2012, 21 (03) : 184 - 188
  • [23] Neutralization of Interleukin-13 increases Skin microbial Diversity: Results of a randomized, double-blind, placebo-controlled Phase III Trial of Tralokinumab in adult Patients with Atopic Dermatitis
    Bieber, Thomas
    Beck, Lisa A.
    Pink, Andrew
    Saeki, Hidehisa
    Eichenfield, Lawrence
    Werfel, Thomas
    Ropke, Mads
    Paller, Amy
    JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2022, 20 : 18 - 18
  • [24] Interleukin-13 promoter gene polymorphism-1112 C/T is associated with atopic dermatitis in Polish patients
    Glen, Jolanta
    Nedoszytko, Boguslaw
    Trzeciak, Magdalena
    Sokolowska-Wojdylo, Malgorzata
    Wilkowska, Aleksandra
    Zablotna, Monika
    Roszkiewicz, Jadwiga
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 : S67 - S67
  • [25] Association analysis of non-synonymous polymorphisms of interleukin-4 receptor-α and interleukin-13 genes in canine atopic dermatitis
    Tanaka, Kazuaki
    Yamamoto-Fukuda, Misaki
    Takizawa, Tatsuya
    Shimakura, Hidekatsu
    Sakaguchi, Masahiro
    JOURNAL OF VETERINARY MEDICAL SCIENCE, 2020, 82 (09): : 1253 - 1259
  • [26] Localization of interleukin-13 gene-expressing cells in tuberculin reactions and lesional skin from patients with atopic dermatitis
    van der Ploeg, I
    Matuseviciene, G
    Fransson, J
    Wahlgren, CF
    Olsson, T
    Scheynius, A
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1999, 49 (04) : 447 - 453
  • [27] Interleukin-13 Promoter Gene Polymorphism-1112 C/T Is Associated with Atopic Dermatitis in Polish Patients
    Glen, Jolanta
    Trzeciak, Magdalena
    Sobjanek, Michal
    Bandurski, Tomasz
    Wilkowska, Aleksandra
    Nedoszytko, Boguslaw
    Roszkiewicz, Jadwiga
    Sokolowska-Wojdylo, Malgorzata
    ACTA DERMATOVENEROLOGICA CROATICA, 2012, 20 (04) : 231 - 238
  • [28] Neutralizing interleukin-13 increases skin microbial diversity: results from a phase III, randomized, double-blind, placebo-controlled trial of tralokinumab in adult patients with atopic dermatitis
    Bieber, T.
    Beck, L. A.
    Pink, A.
    Saeki, H.
    Eichenfield, L.
    Werfel, T.
    Rosholm, A.
    Ropke, M.
    Paller, A.
    BRITISH JOURNAL OF DERMATOLOGY, 2021, 185 (03) : E111 - E112
  • [29] Neutralizing interleukin-13 increases skin microbial diversity: Results from a phase 3, randomized, double-blind, placebo-controlled trial with tralokinumab in adult patients with atopic dermatitis
    Bieber, Thomas
    Beck, Lisa A.
    Pink, Andrew
    Saeki, Hidehisa
    Eichenfield, Lawrence
    Werfel, Thomas
    Rosholm, Anders
    Ropke, Mads
    Paller, Amy
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2021, 85 (03) : AB177 - AB177
  • [30] Differential regulation of epidermal differentiation and its metabolism by interleukin-13 and interleukin-22 in atopic dermatitis
    Mitamura, Y.
    Duphey, S. M.
    Stocker, N.
    D'avino, P.
    Li, M.
    Akdis, C. A.
    Sokolowska, M.
    SWISS MEDICAL WEEKLY, 2023, 153 : 16S - 16S
12345