Decreased cerebrospinal fluid amyloid beta (1-40) levels in frontotemporal lobar degeneration

被引：30
|
作者：
Pijnenburg, Y. A. L.
Schoonenboom, S. N. M.
Mehta, P. D.
Mehta, S. P.
Mulder, C.
Veerhuis, R.
Blankenstein, M. A.
Scheltens, P.
机构：
[1] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, NL-1081 HV Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, NL-1081 HV Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, NL-1081 HV Amsterdam, Netherlands
[4] Inst Basic Res Dev Disibil, Dept Immunol, New York, NY USA
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2007年 / 78卷 / 07期
关键词：
D O I：
10.1136/jnnp.2006.105064
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The role of amyloid metabolism in the pathophysiology of frontotemporal lobar degeneration (FTLD) has yet to be elucidated. We compared CSF levels of amyloid beta 1-40 (A beta 40) and amyloid beta 1-42 (A beta 42) in patients with FTLD (n = 21) versus patients with Alzheimer's disease ( AD, n = 39) and in control subjects ( n = 30). While in AD cases Ab42 levels were lower and CSF Ab40 levels equal to those in controls, a significant decrease in Ab40 and increase in the CSF A beta 42/Ab40 ratio was observed in FTLD compared with AD and control subjects. These findings favour a differential involvement of amyloid beta peptides in FTLD compared with AD.
引用
收藏
页码：735 / 737
页数：3
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