Measurements of linear energy transfer (LET) distributions by CR-39 for a therapeutic carbon ion beam with a new 2D ripple filter

被引:2
|
作者
Yang, Shiyan [1 ,2 ]
Chen, Bo [3 ]
Zhuo, Weihai [2 ,3 ]
Shen, Hao [1 ,2 ]
Zhao, Jingfang [4 ,5 ,6 ]
机构
[1] Fudan Univ, Inst Modern Phys, Dept Nucl Sci & Technol, Shanghai, Peoples R China
[2] Fudan Univ, Key Lab Nucl Phys & Ion beam Applicat MOE, Shanghai, Peoples R China
[3] Fudan Univ, Inst Radiat Med, Shanghai, Peoples R China
[4] Fudan Univ, Canc Hosp, Shanghai Proton & Heavy Ion Ctr, Dept Med Phys, Shanghai, Peoples R China
[5] Shanghai Key Lab Radiat Oncol, Shanghai, Peoples R China
[6] Shanghai Engn Res Ctr Proton & Heavy Ion Radiat Th, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
Carbon-ion therapy; LET spectrum; Ripple filter; Geant4; CR-39; MONTE-CARLO SIMULATIONS; NUCLEAR TRACK DETECTOR; EMPIRICAL-APPROACH; STOPPING POWER; PROTON; SENSITIVITY; QUALITY; SOLIDS; DESIGN; GASES;
D O I
10.1016/j.radphyschem.2022.110193
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
This study aims to measure the linear energy transfer (LET) spectra of therapeutic carbon ion beams with a new 2D 6 mm thick ripple filter (RiFi) by using a CR-39 detector. A water phantom was irradiated by three different single energy carbon beams (86.2 MeV/u, 276.5 MeV/u, and 430.0 MeV/u) at Shanghai Proton and Heavy Ion Center (SPHIC), CR-39 detectors were used to measure the LET spectra with and without the RiFi. The Monte Carlo toolkit Geant4 was employed to perform the simulations. The dose-averaged LET (LETd) was calculated according to the LET spectra. The results showed that the 2D RiFi broadens the Bragg peak width and LETd distribution. The simulation LET spectra of primary carbon ions were in good agreement with the experimental results. The LETd can be well estimated by using the measured LET spectra. This result indicated that the RiFi affects the depth-dose distribution and the shape of LET spectra for mono-energetic carbon beams. The CR-39 detector is suitable for LET spectra measurement. It is hoped that this work could provide a new reference method for the cross-validation of basic data in carbon ion clinical quality assurance and benefit clinical treatment.
引用
收藏
页数:8
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