Beneficial effects of Lactococcus lactis subsp. cremoris LL95 treatment in an LPS-induced depression-like model in mice

被引:14
|
作者
Ramalho, Juliana Bernera [1 ]
Spiazzi, Cristiano Chiapinotto [1 ]
Bicca, Diogo Ferreira [1 ]
Rodrigues, Jessica Ferreira [1 ]
Sehn, Carla Pohl [2 ]
da Silva, Wladimir Padilha [3 ]
Weber, Francis
Cibin, Santos [1 ,4 ]
机构
[1] Univ Fed Pampa UNIPAMPA, Lab Estresse Oxidat, Campus Uruguaiana, BR-97500970 Uruguaiana, RS, Brazil
[2] Univ Fed Pampa UNIPAMPA, Lab Avaliacoes Farmacol & Toxicol Aplicadas Molec, Campus Itaqui, BR-97650000 Itaqui, RS, Brazil
[3] Univ Fed Pelotas UFPel, Dept Ciencia & Tecnol Agroind DCTA, BR-96010900 Pelotas, RS, Brazil
[4] Univ Fed Pampa, Campus Uruguaiana,BR 472 Km 585 Caixa Postal 118, BR-97501970 Uruguaiana, Brazil
关键词
Lactococcus lactis subsp; cremoris; Depression; LPS; Forced swim test; Anti-inflammatory activity; SICKNESS BEHAVIOR; OXIDATIVE STRESS; LIPOPOLYSACCHARIDE; INFLAMMATION; PROBIOTICS; INTERLEUKIN-1-BETA; METAANALYSIS; ACTIVATION; MECHANISMS; IMPROVES;
D O I
10.1016/j.bbr.2022.113847
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Clinical evidence suggests that neuroinflammation, activation of the immune system, and the composition of the intestinal microbiota are involved in the pathology of depression. This study evaluated the effectiveness of a probiotic intervention using Lactococcus lactis subsp. cremoris LL95 in ameliorating mood disorders in a lipopolysaccharide (LPS)-induced depression-like mouse model. C57BL/6 mice were randomly divided into four groups and treated with 5 mg/kg LPS via intraperitoneal injection to induce depression-like symptoms, followed by oral administration of LL95 for one week (1 x 10(9) CFU/mouse). The animals were then subjected to a series of behavioral assessments, including open field, sucrose preference, and forced swimming tests. In addition, we evaluated the levels of reactive oxygen species, tumor necrosis factor-alpha, and interleukin-1 beta in the hippocampal tissues of these animals, and also determined their fecal lactic acid bacteria (LAB) content. LL95 intervention improved LPS-induced depression-like behaviors in mice, including decreased sucrose preference and increased immobility time in the forced swim test. LL95 treatment reversed the LPS-induced increase in hippocampal levels of reactive oxygen species and tumor necrosis factor-alpha, and of interleukin-1 beta to a lesser extent. Furthermore, LL95 intervention increased the fecal LAB content in these animals, suggesting changes in the gut microbiota. These findings suggest that LL95 exerts antidepressant-like effects in LPS-induced depression, which may be attributed to modulation of the oxidative status and pro-inflammatory cytokine expression in the hippocampus and alteration in the LAB content of the gut microbiota.
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页数:7
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