In vitro and in vivo activity of a novel c-Met-targeting antibody-drug conjugate using a DNA-alkylating, indolinobenzodiazepine payload

被引：7
|
作者：
Lai, Katharine C.
Muvaffak, Asli
Li, Min
Themeles, Marian
Sikka, Surina
Donahue, Kerry
Hicks, Stuart W.
Romanelli, Angela
Chittenden, Thomas
机构：
来源：
CANCER RESEARCH | 2017年 / 77卷
关键词：
D O I：
10.1158/1538-7445.AM2017-45
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
45
引用
收藏
页数：2
相关论文
共 50 条
  • [41] In vitro and in vivo activity of DHES0815A, an antibody-drug conjugate targeting HER2/neu in uterine serous carcinoma.
    Tymon-Rosario, Joan Tymon R.
    Bonazzoli, Elena
    Bellone, Stefania
    Manzano, Arancha
    Manara, Paola
    Zammataro, Luca
    Pelligra, Silvia
    Guglielmi, Adele
    Gnutti, Barbara
    Zeybek, Burak
    Harold, Justin
    Mauricio, Dennis
    Ratner, Elena
    Schwartz, Peter
    Santin, Alessandro D.
    CANCER RESEARCH, 2021, 81 (13)
  • [42] First in human dose-escalation trial with the c-MET targeting antibody-drug conjugate BYON3521
    Kotecki, N.
    van Herpen, C. M. L.
    Curigliano, C.
    Hendriks, M.
    Vermaas, T. C.
    Corrigan, L.
    Belli, C.
    Jungels, C.
    Desar, I. M. E.
    Koper, N. P.
    Schellens, J. H. M.
    Banerji, U.
    CANCER RESEARCH, 2023, 83 (08)
  • [43] In vivo activity of a novel CDH6 targeting antibody-drug conjugate, including population-scale ovarian PDX clinical trial
    Bialucha, Carl U.
    Collins, Scott D.
    Shim, Yeonju
    Zhang, Xiamei
    Velazquez, Roberto
    Kowa, Colleen
    Bullock, Caroline
    Cai, Hongbo
    Rivera, Stacy M.
    Goldovitz, Julie M.
    Kurth, Esther
    Loo, Alice T.
    Yang, Guizhi
    Green, John
    Ostrom, Lance
    Meyer, Matthew J.
    Mosher, Rebecca
    Gao, Hui
    Williams, Juliet
    Lees, Emma
    CANCER RESEARCH, 2016, 76
  • [44] Development of a novel antibody-drug conjugate targeting endosialin/TEM-1: potent antitumor activity in sarcoma
    Sala, Gianluca
    Iacobelli, Stefano
    Capone, Emily
    PIccolo, Enza
    Sauniere, Jean-Fred
    Douet, Vanessa Vannucci
    CANCER RESEARCH, 2017, 77
  • [45] MYTX-011: A pH-Dependent Anti-c-MET Antibody-Drug Conjugate Designed for Enhanced Payload Delivery to c-MET-Expressing Tumor Cells
    Gera, Nimish
    Fitzgerald, Kyle M.
    Ramesh, Vijay
    Patel, Purvi
    Kanojia, Deepak
    Colombo, Federico
    Kien, Lena
    Aoyama, Simon
    Xu, Lihui
    Jean, Jussekia
    Deshpande, Amit M.
    Comb, William C.
    Chittenden, Thomas
    Fiske, Brian P.
    MOLECULAR CANCER THERAPEUTICS, 2024, 23 (09) : 1282 - 1293
  • [46] MI130110, a new antibody-drug conjugate combining an anti-CD13 antibody and a payload of marine origin shows remarkable in vivo activity
    Aviles, P.
    Guillen, M. J.
    Dominguez, J. M.
    Zapata, J. M.
    Sanchez-Madrid, F.
    Galmarini, C. M.
    Cuevas, C.
    EUROPEAN JOURNAL OF CANCER, 2016, 69 : S130 - S131
  • [47] Novel antibody-antibiotic conjugate using KRM-1657 as payload eliminates intracellular MRSA in vitro and in vivo
    Fan, Shiyong
    Bai, Yuefan
    Li, Qilong
    Liu, Lianqi
    Wang, Yanming
    Xie, Fei
    Dong, Yuchao
    Wang, Zihao
    Lv, Kai
    Zhu, He
    Bi, Hongkai
    Zhou, Xinbo
    BIOORGANIC CHEMISTRY, 2024, 150
  • [48] DHES0815A, a novel antibody-drug conjugate targeting HER2/neu, is highly active against uterine serous carcinomas in vitro and in vivo
    Tymon-Rosario, Joan
    Bonazzoli, Elena
    Bellone, Stefania
    Manzano, Aranzazu
    Pelligra, Silvia
    Guglielmi, Adele
    Gnutti, Barbara
    Nagarkatti, Nupur
    Zeybek, Burak
    Manara, Paola
    Zammataro, Luca
    Harold, Justin
    Mauricio, Dennis
    Buza, Natalia
    Hui, Pei
    Altwerger, Gary
    Menderes, Gulden
    Ratner, Elena
    Clark, Mitchell
    Andikyan, Vaagn
    Huang, Gloria S.
    Silasi, Dan-Arin
    Azodi, Masoud
    Schwartz, Peter E.
    Santin, Alessandro D.
    GYNECOLOGIC ONCOLOGY, 2021, 163 (02) : 334 - 341
  • [49] A novel dual drug antibody-drug conjugate targeting hTrop2 has synergetic antitumor activity in solid tumor models
    Zhu, Jie
    Zhao, Xiaobei
    Li, Eileen
    Xu, Hong
    Nie, Lei
    Chen, Gang
    Wang, Haibing
    CANCER RESEARCH, 2024, 84 (06)
  • [50] Dose optimization and exposure-response analyses to support optimal dose of ABBV-400, a novel C-met-targeting antibody drug conjugate, in patients with metastatic colorectal cancer (mCRC).
    de Almeida, Carla Biesdorf
    Engelhardt, Benjamin
    Babel, Heiko
    Badillo, Jesus D.
    Sharma, Manish
    Powderly, John D., II
    Aristide, Martha Raluca Neagu
    Freise, Kevin Jay
    Mensing, Sven
    Parikh, Apurvasena
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
12345