Enterococcus faecalis mutations affecting virulence in the Caenorhabditis elegans model host

被引：57
|
作者：
Maadani, Arash
Fox, Kristina A.
Mylonakis, Elftherios
Garsin, Danielle A.
机构：
[1] Univ Texas, Hlth Sci Ctr, Dept Microbiol & Mol Genet, Houston, TX 77030 USA
[2] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA
来源：
INFECTION AND IMMUNITY | 2007年 / 75卷 / 05期
关键词：
D O I：
10.1128/IAI.01372-06
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Enterococcus faecalis transposon insertion mutants were screened for attenuated killing of the nematode model host Caenorhabditis elegans. The genes disrupted in the attenuated mutants encode a variety of factors including transcriptional regulators, transporters, and damage control and repair systems. Five of nine mutants tested were attenuated in a mouse peritonitis model.
引用
收藏
页码：2634 / 2637
页数：4
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