Online solid-phase extraction with high-performance liquid chromatography and mass spectrometry for the determination of five tannins in traditional Chinese medicine injections

被引：8
|
作者：
Sun, Meng [1 ]
Lin, Yuanyuan [1 ]
Zhang, Jie [1 ]
Zheng, Shaohua [2 ]
Wang, Sicen [1 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Pharm, Hlth Sci Ctr, Xian 710061, Peoples R China
[2] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Anesthesiol, Xian 710061, Peoples R China
来源：
JOURNAL OF SEPARATION SCIENCE | 2016年 / 39卷 / 05期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
High-performance liquid chromatography; Mass spectrometry; Quality control; Solid-phase extraction; Tannins; FACTOR RECEPTOR ANTAGONISTS; MEMBRANE CHROMATOGRAPHY; HPLC-DAD; POLYPHENOLS; PRODUCTS; CANCER;
D O I：
10.1002/jssc.201501037
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A rapid analytical method based on online solid-phase extraction with high-performance liquid chromatography and mass spectrometry has been established and applied to the determination of tannin compounds that may cause adverse effects in traditional Chinese medicine injections. Different solid-phase extraction sorbents have been compared and the elution buffer was optimized. The performance of the method was verified by evaluation of recovery (>= 40%), repeatability (RSD <= 6%), linearity (r(2) >= 0.993), and limit of quantification (<= 0.35 mu g/mL). Five tannin compounds, gallic acid, cianidanol, gallocatechin gallate, ellagic acid, and penta-O-galloylglucose, were identified with concentrations ranging from 3.137.4 mu g/mL in the analyzed traditional Chinese medicine injections.
引用
收藏
页码：889 / 894
页数：6
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