3-Methoxytyramine as an indicator of dopaminergic manipulation in the equine athlete

被引：6
|
作者：
Wynne, PM
Vine, JH
Amiet, RG
机构：
[1] Racing Analyt Serv Ltd, Flemington, Vic 3031, Australia
[2] RMIT Univ, Dept Appl Chem, Melbourne, Vic 3001, Australia
来源：
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2004年 / 811卷 / 01期
关键词：
3-methoxytyramine; dopamine manipulation; regulatory threshold;
D O I：
10.1016/j.jchromb.2004.03.078
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The influence of sampling variables on the concentration of the dopamine metabolites 3-methoxytyramine (3MT), dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA) was examined in equine urine. A logarithmic transformation of the data for all horses gave distribution which approximated the normal distributions for each metabolite. The mean urinary concentration of 3MT in horses was 214 ng/mL and the application of a threshold with a probability of 1 in 10,000 gave an actionable level of 4 mug/mL. Environmental variables were not forensically significant in determining the population distribution. HVA was not found to be a reliable indicator of dopamine or levodopa administration. (C) 2004 Elsevier B.V. All rights reserved.
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页码：93 / 101
页数：9
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