Adenovirus related lymphohistiocytic hemophagocytosis: Case report and literature review

被引：9
|
作者：
Mellon, G. [1 ]
Henry, B. [1 ,2 ]
Aoun, O. [3 ]
Boutolleau, D. [2 ,4 ]
Laparra, A. [1 ]
Mayaux, J. [5 ]
Sanson, M. [2 ,6 ]
Caumes, E. [1 ,2 ]
机构：
[1] Grp Hosp Pitie Salpetriere, Serv Malad Infect & Trop, 47-83 Blvd Hop, F-75013 Paris, France
[2] Univ Paris 06, Sorbonne univ, F-75252 Paris 05, France
[3] Ctr Med Armees Strasbourg, Antenne Med Colmar, 2 Rue Beiges BP, F-30446 Colmar, France
[4] Grp Hosp Pitie Salpetriere, Serv Virol, 47-83 Blvd Hop, F-75013 Paris, France
[5] Grp Hosp Pitie Salpetriere, Serv Pneumol & Reanimat Med, 47-83 Blvd Hop, F-75013 Paris, France
[6] Grp Hosp Pitie Salpetriere, Serv Neurol 2, 47-83 Blvd Hop, F-75013 Paris, France
来源：
JOURNAL OF CLINICAL VIROLOGY | 2016年 / 78卷
关键词：
Lymphohistiocytic hemophagocytosis; Adenovirus; Astrocytoma; BONE-MARROW-TRANSPLANTATION; REAL-TIME PCR; INFECTIONS; PNEUMONIA; CIDOFOVIR; THERAPY; TEMOZOLOMIDE; DIAGNOSIS; RIBAVIRIN; DNA;
D O I：
10.1016/j.jcv.2016.03.011
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Introduction: Adenoviral infection is a classic cause of lymphohistiocytic hemophagocytosis (LH) in bone marrow transplantation but is rare outside this setting. Case report: A 31-year-old female, with a history of treated mesencephalic astrocytoma, was hospitalized for fever, pancytopenia, elevated liver enzymes, hyperferritinemia and hypertriglyceridemia. Adenovirus viral load in blood was 7.3 x 10(9) copies/mL. Bone marrow aspirate examination confirmed LH. The patient recovered without specific LH or adenovirus-directed treatment. Conclusion: Adenovirus-related LH, common in bone marrow transplant recipients, should also be considered in patients with chemotherapy in solid tumors. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：53 / 56
页数：4
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