Multifunctional Nanostructured Lipid Carriers: Preparation and Characterizations

被引：0

作者：

Xu, Man ^{[1
]}

Li, Guang-Meng ^{[1
]}

Zhang, Hao-Xiang ^{[1
]}

Chen, Xiao-Ming ^{[1
]}

Xie, Mao-Bin ^{[1
]}

机构：

[1] Guangzhou Med Univ, Sch Basic Med Sci, Dept Biomed Engn, Guangzhou 511436, Guangdong, Peoples R China

来源：

TEXTILE BIOENGINEERING AND INFORMATICS SYMPOSIUM (TBIS) PROCEEDINGS, 2019 | 2019年

基金：

中国国家自然科学基金;

关键词：

Glioma; Nanostructured Lipid Carriers; Temozolomide; Indocyanine Green; DRUG-DELIVERY; NANOPARTICLES SLN; NLC; GLIOMAS; SYSTEM; BRAIN;

D O I：

暂无

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Traditional chemotherapeutic drugs are less effective against glioma, owing to tumour resistance and the blood-brain barrier. In order to maximize their anti-tumour effect, multifunctional nanostructured lipid carriers (NLCs) were prepared and their physico-chemical characterizations are tested in this study. The obtained temozolomide/indocyanine green NLCs (TMZ/ICG-NLCs) possess spherical shapes with a particle size of 155.2 +/- 0.72 nm. The encapsulation efficiency of TMZ and ICG is 41.61% +/- 4.74 and 20.46% +/- 3.54, respectively. TMZ and ICG in NLCs are in an amorphous state and an interaction may occur between the lipids and drugs. TMZ and ICG can be released sequentially within 140 h with a much higher solubility and dissolution rate than the original ones. The excellent physico-chemical properties indicate that TMZ/ICG-NLCs are potential candidates for the treatment of glioma.

引用

页码：187 / 194

页数：8

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