Antibiotics Modulate the Ability of Neutrophils to Release Neutrophil Extracellular Traps

被引：22
|
作者：
Manda-Handzlik, A. [1 ,2 ]
Bystrzycka, W. [3 ]
Sieczkowska, S. [3 ]
Demkow, U. [1 ]
Ciepiela, O. [1 ]
机构：
[1] Warsaw Med Univ, Dept Lab Diagnost & Clin Immunol Dev Age, 63A Zwirki & Wigury St, PL-02091 Warsaw, Poland
[2] Warsaw Med Univ, Postgrad Sch Mol Med, 63A Zwirki & Wigury St, PL-02091 Warsaw, Poland
[3] Warsaw Med Univ, Dept Lab Diagnost & Clin Immunol Dev Age, Student Sci Grp, 63A Zwirki & Wigury St, PL-02091 Warsaw, Poland
来源：
RESPIRATORY TREATMENT AND PREVENTION | 2017年 / 944卷
关键词：
Cefotaxime; Gentamicin; Granulocytes; Phagocytosis; NETs; CLINDAMYCIN; ACTIVATION; NETS;
D O I：
10.1007/5584_2016_59
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Antibiotics directly inhibit the growth and kill microorganisms, and many of them have immunomodulatory properties. We investigated the influence of cefotaxime and gentamicin on the release of neutrophil extracellular traps (NETs) - recently described strategy employed by neutrophils to fight infections. We found that gentamicin inhibits NETs release by human neutrophils, while cefotaxime did not have any impact on this process. The information that antibiotics can modulate NETs release, can be useful in the therapy of infectious diseases in patients suffering from NET-related diseases.
引用
收藏
页码：47 / 52
页数：6
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