Antibiotics Modulate the Ability of Neutrophils to Release Neutrophil Extracellular Traps

被引：22
|
作者：
Manda-Handzlik, A. [1 ,2 ]
Bystrzycka, W. [3 ]
Sieczkowska, S. [3 ]
Demkow, U. [1 ]
Ciepiela, O. [1 ]
机构：
[1] Warsaw Med Univ, Dept Lab Diagnost & Clin Immunol Dev Age, 63A Zwirki & Wigury St, PL-02091 Warsaw, Poland
[2] Warsaw Med Univ, Postgrad Sch Mol Med, 63A Zwirki & Wigury St, PL-02091 Warsaw, Poland
[3] Warsaw Med Univ, Dept Lab Diagnost & Clin Immunol Dev Age, Student Sci Grp, 63A Zwirki & Wigury St, PL-02091 Warsaw, Poland
来源：
RESPIRATORY TREATMENT AND PREVENTION | 2017年 / 944卷
关键词：
Cefotaxime; Gentamicin; Granulocytes; Phagocytosis; NETs; CLINDAMYCIN; ACTIVATION; NETS;
D O I：
10.1007/5584_2016_59
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Antibiotics directly inhibit the growth and kill microorganisms, and many of them have immunomodulatory properties. We investigated the influence of cefotaxime and gentamicin on the release of neutrophil extracellular traps (NETs) - recently described strategy employed by neutrophils to fight infections. We found that gentamicin inhibits NETs release by human neutrophils, while cefotaxime did not have any impact on this process. The information that antibiotics can modulate NETs release, can be useful in the therapy of infectious diseases in patients suffering from NET-related diseases.
引用
收藏
页码：47 / 52
页数：6
相关论文
共 50 条
  • [1] Mlkl Pores Release Neutrophil Extracellular Traps in Necroptotic Neutrophils
    D'Cruz, Akshay A.
    Bliss-Moreau, Meghan
    Ericcson, Maria
    Croker, Ben A.
    [J]. BLOOD, 2015, 126 (23)
  • [2] Filifactor alocis manipulates human neutrophils affecting their ability to release neutrophil extracellular traps induced by PMA
    Armstrong, Cortney L.
    Klaes, Christopher K.
    Vashishta, Aruna
    Lamont, Richard J.
    Uriarte, Silvia M.
    [J]. INNATE IMMUNITY, 2018, 24 (04) : 210 - 220
  • [3] Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps
    Yousefi, S.
    Mihalache, C.
    Kozlowski, E.
    Schmid, I.
    Simon, H. U.
    [J]. CELL DEATH AND DIFFERENTIATION, 2009, 16 (11): : 1438 - 1444
  • [4] Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps
    S Yousefi
    C Mihalache
    E Kozlowski
    I Schmid
    H U Simon
    [J]. Cell Death & Differentiation, 2009, 16 : 1438 - 1444
  • [5] Mercury exposure induces the release of neutrophil extracellular traps and apoptosis in carp neutrophils
    Zhang, Yue
    Zhang, Peijun
    Yu, Peng
    Shang, Xinchi
    Lu, Yuting
    Li, Yuehong
    [J]. AQUACULTURE, 2021, 533
  • [6] The Dermatophyte Trichophyton rubrum Induces Neutrophil Extracellular Traps Release by Human Neutrophils
    Reis, Ana Paula Carvalho
    Celestrino, Giovanna Azevedo
    Igoa, Mariana Villas Boas
    Jesus, Thais Martins
    Franca, Tabata Takahashi
    Moreira, Daniel Valerio Silva
    Rigato, Paula Ordonhez
    Sato, Paula Keiko
    Condino-Neto, Antonio
    Noronha, Irene L.
    Dias-Melicio, Luciane Alarcao
    Lalwani, Pritesh Jaychand
    Benard, Gil
    Sousa, Maria Gloria Teixeira
    [J]. JOURNAL OF FUNGI, 2022, 8 (02)
  • [7] Neutrophil extracellular traps - the dark side of neutrophils
    Sorensen, Ole E.
    Borregaard, Niels
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (05): : 1612 - 1620
  • [8] Melanoma-derived soluble mediators modulate neutrophil biological properties and the release of neutrophil extracellular traps
    Modestino, Luca
    Cristinziano, Leonardo
    Trocchia, Marialuisa
    Ventrici, Annagioia
    Capone, Mariaelena
    Madonna, Gabriele
    Loffredo, Stefania
    Ferrara, Anne Lise
    Romanelli, Marilena
    Simeone, Ester
    Varricchi, Gilda
    Rossi, Francesca Wanda
    de Paulis, Amato
    Marone, Gianni
    Ascierto, Paolo Antonio
    Galdiero, Maria Rosaria
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2023, 72 (10) : 3363 - 3376
  • [9] Melanoma-derived soluble mediators modulate neutrophil biological properties and the release of neutrophil extracellular traps
    Luca Modestino
    Leonardo Cristinziano
    Marialuisa Trocchia
    Annagioia Ventrici
    Mariaelena Capone
    Gabriele Madonna
    Stefania Loffredo
    Anne Lise Ferrara
    Marilena Romanelli
    Ester Simeone
    Gilda Varricchi
    Francesca Wanda Rossi
    Amato de Paulis
    Gianni Marone
    Paolo Antonio Ascierto
    Maria Rosaria Galdiero
    [J]. Cancer Immunology, Immunotherapy, 2023, 72 : 3363 - 3376
  • [10] Neutrophils contribute to vasculitis by increased release of neutrophil extracellular traps in Behcet's disease
    Safi, Remi
    Kallas, Romy
    Bardawil, Tara
    Mehanna, Carl Joe
    Abbas, Ossama
    Hamam, Rola
    Uthman, Imad
    Kibbi, Abdul-Ghani
    Nassar, Dany
    [J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2018, 92 (02) : 143 - 150
12345