A study on the supramolecular structure of inclusion complex of β-cyclodextrin with prazosin hydrochloride

The supramolecular structure of the inclusion complex of beta-cyclodextrin (PCD) with prazosin hydrochloride (PRH) has been investigated. The 1: 1 stoichiometry of complexation was achieved by phase solubility study and the inclusion complex with 1: 1 molar ratio was prepared by co-precipitation method. DSC analysis confirmed that the inclusion complex was formed. XRD patterns of beta CD and inclusion complex indicated that the structures of them belonged to the channel-type packing structure, and the axial structure period was two times the depth of beta CD torus. The fragment of PRH molecule which entrapped into the beta CD cavity was proposed on the basis of Fourier transformation-infrared analysis and the predicted model indicated that the furan ring and the conjunctive carbonyl group of PRH molecule were inserted into the beta CD cavity. (c) 2006 Elsevier Ltd. All rights reserved.