Applying Computational Fluid Dynamics Technology in Bioprocesses

capabilities of computational fluid dynamics (CFD) as a tool for troubleshooting and Quality by Design have been demonstrated through case studies in bioprocesses from upstream, to downstream, to fill finish. The applications involve, for example, multiple physics, fluid dynamics, transport phenomenon, heat transfer, phase transition, and rheology. Flow types include laminar flow in emulsification, turbulent flow in bioreactor mixing, and porous media flow in chromatographic columns, filtration, and centrifuge machine. Part 1 of this article series is an overview of the technology, followed by a discussion of the model setup. Part 2 of this series will discuss how CFD is used to perform flow characterization, mixing, resuspension, fermentation, and cell culture.