Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients

被引：6
|
作者：
Jou, Erin [1 ]
Gligich, Oleg [1 ]
Chan, Alvita C. Y. [2 ,3 ]
Mohan, Diwakar [4 ]
Felsen, Uriel R. [5 ]
Ayyappan, Sabarish [6 ]
Billett, Henny H. [1 ]
Hui, Edwin P. [2 ,3 ]
Chan, Anthony T. [2 ,3 ]
Raghupathy, Radha [2 ,3 ]
机构：
[1] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Oncol, Div Hematol, Bronx, NY 10467 USA
[2] Chinese Univ Hong Kong, Hong Kong Canc Inst, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc,Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China
[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA
[5] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Internal Med, Div Infect Dis, Bronx, NY 10467 USA
[6] Univ Hosp Case Med Ctr, Dept Hematol & Oncol, Cleveland, OH USA
来源：
HEMATOLOGICAL ONCOLOGY | 2017年 / 35卷 / 01期
关键词：
HIV; hematological malignancy; oligoclonal proteins; monoclonal proteins; paraproteins; OLIGOCLONAL IMMUNOGLOBULINS; LONG-TERM; FOLLOW-UP; PARAPROTEINEMIA; SERUM; AIDS; MYELOMA;
D O I：
10.1002/hon.2247
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n=266) and HIV- (n=537) patients with monoclonal gammopathies. HIV+ and HIV- patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIV- SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV- (6.4% vs 15.4%, p<0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP. Copyright (c) 2015 John Wiley & Sons, Ltd.
引用
收藏
页码：64 / 68
页数：5
相关论文
共 50 条
  • [41] COVID-19 in hospitalized HIV-positive and HIV-negative patients: A matched study
    Diez, Cristina
    Del Romero-Raposo, Jorge
    Mican, Rafael
    Lopez, Juan C.
    Blanco, Jose R.
    Calzado, Sonia
    Samperiz, Gloria
    Portilla, Joaquin
    Garcia-Fraile, Lucio J.
    Gutierrez, Felix
    Gomez-Sirvent, Juan L.
    Suarez-Garcia, Ines
    Amador, Concha
    Novella, Maria
    Arribas, Jose R.
    Moreno, Santiago
    Gonzalez-Garcia, Juan
    Jarrin, Inmaculada
    Berenguer, Juan
    HIV MEDICINE, 2021, 22 (09) : 867 - 876
  • [42] COMPARATIVE-STUDY OF CONJUNCTIVAL FLORA IN HIV-POSITIVE PATIENTS AND HIV-NEGATIVE CONTROLS
    KARCIOGLU, ZA
    AKULA, S
    HILDEBRAND, P
    MERA, R
    ALHUSSAINI, A
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1994, 35 (04) : 1309 - 1309
  • [43] CERVICAL HPV INFECTION AND RELATED SIL - A COMPARATIVE-STUDY IN HIV POSITIVE AND HIV NEGATIVE PATIENTS
    TENTI, P
    CARNEVALI, L
    ZAPPATORE, R
    SPINILLO, A
    ROSSO, R
    LABORATORY INVESTIGATION, 1992, 66 (01) : A69 - A69
  • [44] CONDYLOMATA ACUMINATA OF THE ANUS - PROSPECTIVE-STUDY OF HIV-POSITIVE AND HIV-NEGATIVE PATIENTS
    BUCHMANN, P
    CHRISTEN, D
    RUDLINGER, R
    GEROULANOS, S
    CHIRURG, 1991, 62 (01): : 32 - 35
  • [45] Comparison Of The Presentation Of Tuberculosis In Hiv Positive Versus Hiv Negative/unknown Patients In An Underserved Nyc Hospital In The Haart Era
    Cancio, N.
    Arshad, H.
    Gomez-Marquez, J.
    Venkatram, S.
    Diaz-Fuentes, G.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 191
  • [46] Prevalence of QT-prolongation in HIV positive patients - results from the HIV-HEART study
    Reinsch, N.
    Buhr, C.
    Krings, P.
    Konorza, T.
    Kaelsch, H.
    Neumann, T.
    Erbel, R.
    EUROPEAN HEART JOURNAL, 2007, 28 : 405 - 405
  • [47] PREVALENCE, INCIDENCE AND RISK FACTORS FOR HEPATITIS C IN HIV NEGATIVE AND HIV POSITIVE HOMOSEXUAL MEN
    Jin, F.
    Prestage, G. P.
    Dore, G. J.
    Zablotska, I.
    Rawstorne, P.
    Kippax, S. C.
    Kaldor, J. M.
    Grulich, A. E.
    SEXUAL HEALTH, 2008, 5 (04) : 389 - 389
  • [48] Prevalence and risk of progression of light-chain monoclonal gammopathy of undetermined significance: a retrospective population-based cohort study
    Dispenzieri, Angela
    Katzmann, Jerry A.
    Kyle, Robert A.
    Larson, Dirk R.
    Melton, L. Joseph, III
    Colby, Colin L.
    Therneau, Terry M.
    Clark, Raynell
    Kumar, Shaji K.
    Bradwell, Arthur
    Fonseca, Rafael
    Jelinek, D. F.
    Rajkumar, S. Vincent
    LANCET, 2010, 375 (9727): : 1721 - 1728
  • [49] The histology of nasopharyngeal masses: a comparison between HIV positive and HIV negative patients
    T. Erasmus
    T. Daniller
    J. Goedhals
    G. Joubert
    R. Y. Seedat
    European Archives of Oto-Rhino-Laryngology, 2013, 270 : 755 - 759
  • [50] Infectious disease immunohistochemistry in placentas from HIV positive and HIV negative patients
    Schuetz, A. N.
    Oprea-Ilies, G.
    Packard, M.
    Zaki, S. R.
    Guarner, J.
    MODERN PATHOLOGY, 2007, 20 : 269A - 269A
12345