Stochastic Emergence of Two Distinct Self-Replicators from a Dynamic Combinatorial Library

被引:7
|
作者
Schaeffer, Gael [1 ]
Eleveld, Marcel J. [1 ]
Ottele, Jim [1 ]
Kroon, Peter C. [1 ,2 ,3 ]
Frederix, Pim W. J. M. [1 ,2 ,3 ]
Yang, Shuo [1 ]
Otto, Sijbren [1 ]
机构
[1] Univ Groningen, Ctr Syst Chem, Stratingh Inst, NL-9747 AG Groningen, Netherlands
[2] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, NL-9747 AG Groningen, Netherlands
[3] Univ Groningen, Zernike Inst Adv Mat, NL-9747 AG Groningen, Netherlands
关键词
Chemical systems - Deterministics - Dynamic combinatorial library - Experimental conditions - Nucleation process - Property - Random fluctuation - Replicators - Stochastics - Synthetic chemicals;
D O I
10.1021/jacs.1c12591
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Unraveling how chemistry can give rise to biology is one of the greatest challenges of contemporary science. Achieving life-like properties in chemical systems is therefore a popular topic of research. Synthetic chemical systems are usually deterministic: the outcome is determined by the experimental conditions. In contrast, many phenomena that occur in nature are not deterministic but caused by random fluctuations (stochastic). Here, we report on how, from a mixture of two synthetic molecules, two different self-replicators emerge in a stochastic fashion. Under the same experimental conditions, the two self-replicators are formed in various ratios over several repeats of the experiment. We show that this variation is caused by a stochastic nucleation process and that this stochasticity is more pronounced close to a phase boundary. While stochastic nucleation processes are common in crystal growth and chiral symmetry breaking, it is unprecedented for systems of synthetic self-replicators.
引用
收藏
页码:6291 / 6297
页数:7
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