Relationship between the GDx VCC and Stratus OCT in Primary Open Angle Glaucoma

Purpose: To compare the ability of scanning laser polarimetry (GDx VCC), and optical coherence tomography (OCT) to discriminate eyes with primary open angle glaucoma (POAG) from normal eyes and to assess the relationship between their parameters Methods: Eighty-seven glaucomatous eyes of 87 patients and 25 normal eyes were enrolled. The mean age of patients and normal group were 54.96 +/- 18.34 and 50.02 +/- 20.15, respectively. All subjects underwent a full ophthalmic examination, automated perimetry, GDx VCC and OCT. Correlation coefficients between the parameters of OCT and GDx VCC were calculated. We calculated area under the receiver operating characteristic curve (AROC) for GDx VCC and OCT main parameters. Results: Statistically significant correlations were observed between GDx VCC and OCT parameters. Pearson coefficients ranged from 0.731 for inferior average to -0.858 for nerve fiber indicator (NFI)/average thickness of OCT. The greatest area under AROC parameter in OCT (inferior average 0.97) had a lower area than that in GDx VCC (NFI; 0.99). There was a significant statistical correlation in all visual field (VF), GDx VCC, and OCT variables between two groups. Conclusion: Many parameters of GDx VCC were significantly correlated with those of the OCT. Inferior average and NFI had the greatest area under AROC parameter in OCT and GDx VCC, respectively. NFI had high sensitivity and specificity for the diagnosis of POAG.