Relationship between GDx VCC and Stratus OCT in juvenile glaucoma

Purpose To compare the ability of scanning laser polarimetry (GDx VCC) and optical coherence tomography (OCT) to discriminate eyes with juvenile glaucoma from normal eyes and to assess the relationship between their parameters. Methods A total of 24 glaucomatous eyes of 24 patients and 24 normal eyes were enrolled. The age range of the patient was 11-40 years with a mean age of 25.1 +/- 8.2 years. Contol groups consisted 24 eyes of 24 individuals without glaucoma with a mean age of 33.2 +/- 8.2 years. All subjects underwent a full ophthalmic examination, automated perimetry, GDx VCC, and OCT. Correlation coefficients between the parameters of OCT and GDx VCC were calculated. We calculated the area under the receiver operating characteristic curve (AROC) for the main parameters of GDx VCC and OCT. Results Statistically significant correlations were observed between GDx VCC and OCT parameters. Pearson coefficients ranged from 0.75 for inferior average to 0.86 for nerve fibre indicator (NFI)/average thickness OCT. The greatest AROC parameter in OCT (inferior average: 0.92) had a lower area than that in GDx VCC (NFI: 0.99). There was a significant statistical significance in all visual field, GDx VCC, and OCT variables between two groups (P<0.05). Conclusions Many GDx VCC parameters were significantly correlated with those of the OCT in patients with juvenile glaucoma. Inferior average and NFI had the greatest AROC parameter in OCT and GDx VCC, respectively. NFI had high sensitivity and specificity for the diagnosis of JOAG. Eye (2009) 23, 2182-2186; doi:10.1038/eye.2009.15; published online 20 February 2009