Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa

被引：43

作者：

Janas-Kozik, Malgorzata

Krupka-Matuszczyk, Irena

Malinowska-Kolodziej, Izabela

Lewin-Kowalik, Joanna

机构：

[1] John Paul II Pediat Ctr, Child & Adolescents Psychiat & Psychotherapy Ward, PL-41218 Sosnowiec, Poland

[2] Med Univ Silesia, Dept & Clin Psychiat & Psychotherapy, PL-40635 Katowice, Poland

[3] Med Univ Silesia, Dept Physiol, PL-40752 Katowice, Poland

来源：

REGULATORY PEPTIDES | 2007年 / 140卷 / 1-2期

关键词：

orexigenic; peptide; BMI; eating; disorders;

D O I：

10.1016/j.regpep.2006.11.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ghrelin is produced mainly in the stomach and is an essential link of the brain-gut axis. Ghrelin stimulates hunger centers in hypothalamus controlling food intake and body mass gain. The aim of the study is to analyze the total ghrelin plasma level in patients suffering from restrictive type of anorexia nervosa (AN-R). According to DSM-IV classification a group of 30 AN-R patients was investigated before and after 3 and 6 months of therapy. Therapy included normocaloric diet and cognitive-behavioral psychotherapy (CBT). The control group consisted of 20 girls without any eating disorders. Before the therapy the total ghrelin plasma level in AN-R patients was significantly higher than in the control group. After 3 and 6 months of treatment the total ghrelin plasma level in AN-R patients was significantly lower than in the control group. In AN-R patients, the total ghrelin plasma level is connected with the pathological feeding behavior. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：43 / 46

页数：4

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